Project Details
Projekt
Mechanisms underlying the role of HDAC9 in atherosclerosis (B03)
Subject Area
Cardiology, Angiology
Term
since 2014
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 238187445
Our preliminary work indicates that targeted deletion of the rs2107595-containing cis-regulatory element (cisRE) exacerbates atherosclerosis and upregulates HDAC9 expression in myeloid cells. Profiling of circulating cytokines including IL-1β, IL-18, and IL-6 along with caspase-1 cleavage and activation assays in macrophages points towards effects on inflammasome signaling. We now aim to expand on these results by addressing the following: (Aim 1) detail the impact of the cisRE at HDAC9 on atherosclerosis; (Aim 2) unravel the molecular role of HDAC9 in NLRP3 inflammasome activation; and (Aim 3) explore nano-immunotherapeutic targeting of HDAC9 for plaque stabilization.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ludwig-Maximilians-Universität München
Project Heads
Dr. Yaw Asare; Professor Dr. Martin Dichgans; Privatdozent Dr. Christof Haffner, until 6/2018
