Project Details
Projekt
CCR8-driven immune functions of group 2 innate lymphoid cells (ILC2s) in atherosclerosis (A01)
Subject Area
Cardiology, Angiology
Term
since 2014
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 238187445
How CCR8 controls ILC2 function in chronic vascular inflammation is not understood. Thus, we will (Aim 1) characterize CCR8-expressing ILC2s in vitro interrogating their transcriptomic profile, phenotype as well as their metabolic profile and potential plasticity in response to atherogenic mediators. Further, (Aim 2) we will focus on the role of ILC2s in vivo using cell- specific inducible Cre/flox mouse models to detail on the relevance of ILC2s and CCR8-expressing ILC2s in atherosclerosis. In Aim 3 we elucidate the interplay of CCL17+ DCs and ILC2s in atherosclerosis and follow up on a clinical translation of our findings also with respect to therapeutic interventions.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ludwig-Maximilians-Universität München
Project Heads
Dr. Yvonne Döring; Professor Dr. Christian Weber
