TRPC cation channels in hypoglycemia-associated autonomic nervous system failure in diabetes models (B02)

• Subject Area: Pharmacology ; Endocrinology, Diabetology, Metabolism
• Term: from 2014 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 236360313

In B02 we aim to identify relevant neurons and neuroendocrine cells in the brain stem and adrenal medulla, respectively, that rely on TRPC channels during sympatho-adrenal counter-regulation to hypoglycemia. TRPC channel functions and their impact for cellular Ca2+ homeostasis and Ca2+ dependent exocytosis of catecholamines will be analysed. Based on hitherto and further metabolome studies the project aims to develop new interventional therapeutic approaches for „Hypoglycemia-associated autonomic failure“.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1118: Reactive metabolites as a cause of diabetes complications
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Marc Freichel