Functional interplay of reactive metabolites in diabetic organ damage (B01)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: from 2014 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 236360313

Loss of glyoxalase1 (glo1) in zebrafish leads to a partial methylglyoxal increase only and was accompanied by an impaired glucose tolerance. ALDH3a1, AKR1a1a and ALDH2.1 were compensatory upregulated in glo1 mutants and detoxify different reactive metabolites. By using glo1/akr1a1a, glo1/aldh3a1 and glo1/aldh2.1 double mutants we will now test the accumulation of reactive metabolites in the different enzyme constellation and address how this leads to organ damages and if physical exercise will alter the enzyme activity and accumulation of reactive metabolites.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1118: Reactive metabolites as a cause of diabetes complications
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Jens Kroll