Novel TRP channel functions in olfaction (P10)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239283807

This project investigates novel functional roles for TRP channels in neuronal processing and homeostatic regulation of the mammalian olfactory system and closely related chemosensory systems. The project will focus on the function and signaling mechanisms of TRPM5 in pathogen sensing and defensive responses of the nasal respiratory epithelium, TRPM4 in hormonal modulation of vomeronasal sensory neurons, and TRPC5 and TRPC6 in rhythmically active brain neurons of the hypothalamus that underlie neuroendocrine control. These experiments will provide a concerted effort for a detailed understanding of novel TRP channel functions in peripheral and central olfactory regions.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 152: TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professorin Dr. Trese Leinders-Zufall; Professor Dr. Frank Zufall