Project Details
Projekt
Structure-function analysis of nuclear export complexes and their interaction with nucleoporins (B08)
Subject Area
Biochemistry
Term
from 2014 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 105286809
CRM1 is the major nuclear export receptor for proteins and also for a subset of RNAs. In the first part of this project, we plan to analyse the significance of the interaction of CRM1 with an NES-like sequence in the nucleoporin Nup214 for nuclear transport and also for the biogenesis of the nuclear pore complex. In the second part, we want to investigate CRM1-containing RNA-export complexes by means of single-particle cryo-electron microscopy (cryo-EM), X-ray crystallography and mass spectrometry.
DFG Programme
Collaborative Research Centres
Applicant Institution
Georg-August-Universität Göttingen
Project Heads
Professor Dr. Ralf Ficner; Professor Dr. Ralph Kehlenbach
