Evaluation and application of a novel radioisotope for immuno-PET:Niobium-90

• Applicant: Professor Dr. Frank Rösch
• Subject Area: Nuclear Medicine, Radiotherapy, Radiobiology
• Term: from 2014 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 256296058

• Final Report Year: 2019

Final Report Abstract

As results of this project we showed high potential of 90Nb to become an additional tool for immuno-PET for imaging of antibody fragments and smaller biomolecules. We were able to design and test efficient production and radiochemical separation with can be implemented in hospitals on medical cyclotrons. We found that DFO is most suitable chelator for Nb among other existing and commonly used chelators. We performed preliminary in vivo evaluation of Nb labelled compounds and showed high complex stability even superior to Zr. We plan to extend this research in the future.

Publications

• Desferrioxamine as an Appropriate Chelator for 90Nb: Comparison of its Complexation proprieties for M-Df-Octreotide (M = Nb, Fe, Ga, Zr). Nuclear Medicine and Biology. 2014 41(9): 721-727
  Radchenko V., Busse S., Roesch F.
  
• Direct Flow Separation Strategy, to Isolate NoCarrier-Added 90Nb from Irradiated Mo or Zr target. Radiochimica Acta. 2016 104(9): 265634
  Radchenko V., Filosofov D. V, Dadakhanov J., Karaivanov D. V. Marinova A., Baimukhanova A., Roesch F.
  
• Labeling and Preliminary In Vivo Assessment of Niobium-Labeled Radioactive Species: A Proof-of-Concept Study. Nuclear Medicine and Biology. 2016 43(5): 280-287
  Radchenko V., Bouziotis P., Tsotakos T., Paravatou-Petsotas M., de la Fuente A., Loudos G., Harris A.L., Xanthopoulos S., Filosofov, D., Hauser H., Eisenhut M., Ponsard B., Roesch F.
  
• Conjugation, labelling and in vitro/in vivo assessment of an anti-VEGF monoclonal antibody labelled with niobium isotopes. Journal of Radioanalytical and Nuclear Chemistry. 2018 318(5):1991-1997
  de la Fuente, V. Radchenko, T. Tsotakos, C. Tsoukalas, M. Paravatou-Petsotas, A. L. Harris, U. Köster, F. Rösch