Project Details
Projekt
The role of the atypical NF-κB inhibitory protein IκBNS in effector cells (A23)
Subject Area
Immunology
Term
from 2014 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925
NF-κB is an important transcription factor for immune cell development and function and is regulated by IκB proteins. IκBNS is an unusual IκB protein and functionally poorly characterized. During the 2nd funding period, A23 established that IκBNS-/- mice are resistant towards high-dose Listeria infection, hinting towards alterations in innate immunity. Indeed, we found extraordinarily high expression of IκBNS in macrophages/monocytes, neutrophils and NK cells using reporter mice. In the next funding period, we will decipher molecular and cellular functions of IκBNS in these cells using newly established conditional knockout mice that are currently being characterized. This includes IκBNS-dependent leucocyte migration during Listeria infection and functional characterization of target genes and microRNAs.
DFG Programme
Collaborative Research Centres
Applicant Institution
Otto-von-Guericke-Universität Magdeburg
Project Heads
Professorin Dr. Dunja Bruder; Professor Dr. Ingo Schmitz
