Understanding the molecular machinery driving basic cellular processes with relevance to the pathogenesis of cancer and auto immune disorders

• Applicant: Professor Dr. Krishnaraj Rajalingam
• Subject Area: Cell Biology
• Term: from 2014 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 250873790

• Final Report Year: 2021

Final Report Abstract

No abstract available

Publications

• Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2. EMBO Reports, Vol. 18. 2017, Issue 5, pp. 733-744.
  Imre G., Berthelet J., Heering J., Kehrloesser S., Melzer I.M., Lee B.I., Thiede B., Dötsch V., Rajalingam K.
  (See online at https://doi.org/10.15252/embr.201643744)
• Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours. Oncogene, Vol. 36. 2017, Issue 33, pp. 4778–4789.
  Yurugi H., Marini F., Weber C., David K., Zhao Q., Binder H., Desaubry L., Rajalingam K.
  (See online at https://doi.org/10.1038/onc.2017.93)
• Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity. EMBO Journal, Vol. 37. 2018, Issue 16, e99429.
  Buehler U., Schulenburg K., Yurugi H., Šolman M., Abankwa D., Ulges A., Tenzer S., Bopp T., Thiede B., Zipp F., Rajalingam K.
  (See online at https://doi.org/10.15252/embj.201899429)
• The Myb-related protein MYPOP is a novel intrinsic host restriction factor of oncogenic human papillomaviruses. Oncogene, Vol. 37. 2018, Issue 48, pp. 6275–6284.
  Wüstenhagen E., Boukhallouk F., Negwer I., Rajalingam K., Stubenrauch F., Florin L.
  (See online at https://doi.org/10.1038/s41388-018-0398-6)
• Intestinal development and homeostasis require activation and apoptosis of diet reactive T cells. Journal of Clinical Investigation, Vol. 129. 2019, Issue 5, pp. 1972-1983.
  Visekruna A., Hartmann S., Sillke Y.R., Glauben R., Fischer F., Raifer H., Mollenkopf H., Bertrams W., Schmeck B., Klein M., Pagenstecher A., Lohoff M., Jacob R., Pabst O., Bland P.W., Luu M., Romero R., Siegmund B., Rajalingam K., Steinhoff U.
  (See online at https://doi.org/10.1172/JCI98929)
• ERK3/MAPK6 controls IL-8 production and chemotaxis. eLife, Vol. 9. 2020: e52511.
  Bogucka K., Pompaiah M., Marini F., Binder H., Harms G., Kaulich M, Klein M., Michel C., Radsak M.P., Rosigkeit S., Grimminger P., Schild H., Rajalingam K.
  (See online at https://doi.org/10.7554/eLife.52511)
• Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas. Nature Communications, Vol. 11. 2020, Article number: 2056.
  Krishnan A, Berthelet J, Renaud E, Rosigkeit S, Distler U, Stawiski E, Wang J., Modrusan Z., Fiedler M., Bienz M., Tenzer S., Schad A., Roth W., Thiede B., Seshagiri S., Musholt T.J., Rajalingam K.
  (See online at https://doi.org/10.1038/s41467-020-15955-w)
• RAF kinases are stabilized and required for dendritic cell differentiation and function. Cell Death & Differentiation, Vol. 27. 2020, Issue 4, pp. 1300–1315.
  Riegel K., Schlöder J., Sobczak M., Jonuleit H., Thiede B., Schild H., Rajalingam K.
  (See online at https://doi.org/10.1038/s41418-019-0416-4)