Oxidative stress: enzymatic detoxification of reactive carbonyl compounds in simple model organisms and man

• Applicant: Professor Dr. Edmund Maser
• Subject Area: Public Health, Healthcare Research, Social and Occupational Medicine
• Term: from 2014 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 248793591

• Final Report Year: 2017

Final Report Abstract

No abstract available

Publications

• (2018) Crystal structure and catalytic characterization of the dehydrogenase/reductase SDR family member 4 (DHRS4) from Caenorhabditis elegans. The FEBS journal 285 (2) 275–293
  Kisiela, Michael; Faust, Annette; Ebert, Bettina; Maser, Edmund; Scheidig, Axel J.
  
• (2015) Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase - Carbonyl reductase 1. Chem Biol Interact 234:162-168
  Hintzpeter J, Hornung J, Ebert B, Martin HJ, and Maser E
  
• (2016). Transcriptional regulation of human and murine short-chain dehydrogenase/reductases (SDRs) –An in silico approach. Drug metabolism reviews 48, 183-217
  Bettina Ebert, Michael Kisiela and Edmund Maser