H2O2 perception and signal transduction: the specific role of AHK5 (B05)

• Subject Area: Plant Physiology ; Structural Biology
• Term: from 2014 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 232631280

The structures of different AHK5 protein domains are to be solved and structural information combined with functional studies. This wil help to understand how the AHK5 peceives H2O2 or redox conditions in vitro and in vivo. Experiments with AHK5 mutants will demonstrate the extent to which histidine kinase activity, phosphorylay capacity, and cross-talk in classical Ser / Thr / Tyr phosphorylation pathways are required for the AHK5-specific plant responses. In addition, the identification of other factors contributing to AHK5-specific signaling and function in the context of H2O2 as a signaling molecule is planned.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1101: Molecular Encoding of Specificity in Plant Processes
• Applicant Institution: Eberhard Karls Universität Tübingen
• Project Heads: Professor Dr. Klaus Harter; Professor Dr. Thilo Stehle