Regulation of B cell differentiation by vitamin A and D (19+)

• Subject Area: Immunology
• Term: from 2013 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 215346292

Vitamin A and vitamin D both regulate B cell function and are linked on a molecular level as their receptors dimerize. Project 19 could show that both vitamin A and D synergistically block IgE production. Furthermore, vitamin A could induce a class switch to IgA. The mechanisms for these pathways will be further analysed in human B cells and mouse models. These studies may provide a molecular basis for the development of novel anti-allergic treatment protocols.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 130: B Cells: Immunity and Autoimmunity
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Co-Applicant Institution: Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Guido Heine; Professorin Dr. Margitta Worm