Evolution of anti-DNA autoantibodies by somatic hypermutation (11+)

• Subject Area: Immunology
• Term: from 2013 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 215346292

The formation of antibodies against DNA is considered to be the serologic hallmark of systemic lupus erythematosus (SLE) and anti-DNA antibodies play an important role in the pathogenesis of the disease. Anti-DNA antibodies from autoimmune mice and SLE patients can arise by somatic mutation. Using a genetic mouse model, Project 11 could show that the backcrossed germline version of the antibody genes coding for anti-DNA autoantibodies does not induce tolerance mechanisms leading to deleting or silencing the expressed antibodies. Conditions how genetic factors and immunisations can trigger anti-DNA antibody development will be further studied. Project 11 will also examine SLE development in a new mouse line with defects in clearance of apoptotic cells.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 130: B Cells: Immunity and Autoimmunity
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Head: Professor Dr. Thomas Winkler