GSC 97:  Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB)

• Subject Area: Medicine
• Term: from 2006 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 24185540

• Final Report Year: 2020

Final Report Abstract

The Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB), founded in 2006, currently hosts 112 PhD students and 72 Research groups. Together with its partner program, the International Max Planck Research School for Cell, Developmental and Systems Biology (IMPRS- CellDevoSys) it has become one of the largest international PhD programs in the field of life sciences in Germany. As an innovative cross-faculty institution of the TU Dresden it serves as a model for the university- wide doctoral system. Approximately 700 junior scientists from all over the world apply each year for admission to one of its six highly interconnected scientific research tracks “Cell, Molecular and Developmental Biology”, “Biomedicine”, “Regenerative and Degenerative Biology”, “Bioengineering and Biomaterials”, “Biophysics” and “Computational Biology”. By educating and supporting the selected young scientists, the DIGS-BB is key for the high standards and extraordinary dynamics that drive the life sciences at TUD. The factors that ensure the quality of DIGS-BB PhD students are (i) the highly competitive selection process of the applicants; (ii) a supervision concept that is tailored for each doctoral candidate individually; (iii) a support structure that offers state-of-the art technologies including experts in the fields; and (iv) a training concept that has been adapted to reflect the interdisciplinary orientation of the research projects. Thanks to the support gained through the privileged recruitment of excellent doctoral candidates and the anchoring and integration in the strong interdisciplinary community of Biopolis Dresden, the DIGS-BB is also an excellent career-advancing institution for junior research group leaders and postdocs. In the second funding period, the DIGS-BB extended the support and supervision aspects to the postdoctoral phase, as well as to BSc and Master students via DIGS-BB research internship programs. Also, PhD students profited from opportunities offered to outreach their research data, as well as to receive career advice along the PhD time. Furthermore, junior group leaders have been supported by the status of “TUD Young Investigators” that allows this high-performing group the supervision of PhD students, participation in doctorate proceedings as reviewers and examiners and integration in the respective Faculties. By pursuing the successful path run since its foundation in 2006 and by continually improving its offers, the DIGS- BB has successfully established itself as an internationally recognized and leading graduate center.

Link to the final report

https://doi.org/10.2314/KXP:1699289700

Publications

• Acute inflammation initiates the regenerative response in the adult zebrafish brain. Science. 2012 Dec 7;338(6112):1353-6
  Kyritsis N, Kizil C, Zocher S, Kroehne V, Kaslin J, Freudenreich D, Iltzsche A, Brand M
  (See online at https://doi.org/10.1126/science.1228773)
• Combined RNAi and localization for functionally dissecting long noncoding RNAs. Nat Methods. 2012 Feb 12;9(4):360-2
  Chakraborty D, Kappei D, Theis M, Nitzsche A, Ding L, Paszkowski-Rogacz M, Surendranath V, Berger N, Schulz H, Saar K, Hubner N, Buchholz F
  (See online at https://doi.org/10.1038/nmeth.1894)
• Elastic volume reconstruction from series of ultra-thin microscopy sections. Nat Methods. 2012 Jun 10;9(7):717-20
  Saalfeld S, Fetter R, Cardona A, Tomancak P
  (See online at https://doi.org/10.1038/nmeth.2072)
• Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012 Jun 28;9(7):676-82
  Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez JY, White DJ, Hartenstein V, Eliceiri K, Tomancak P, Cardona A
  (See online at https://doi.org/10.1038/nmeth.2019)
• Forces driving epithelial spreading in zebrafish gastrulation. Science. 2012 Oct 12;338(6104):257- 60
  Behrndt M, Salbreux G, Campinho P, Hauschild R, Oswald F, Roensch J, Grill SW, Heisenberg CP
  (See online at https://doi.org/10.1126/science.1224143)
• Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1. Cell. 2012 Oct 26;151(3):603-18
  Okaz E, Argüello-Miranda O, Bogdanova A, Vinod PK, Lipp JJ, Markova Z, Zagoriy I, Novak B, Zachariae W
  (See online at https://doi.org/10.1016/j.cell.2012.08.044)
• Omnidirectional microscopy. Nat Methods. 2012 Jun 28;9(7):656-7
  Weber M, Huisken J
  (See online at https://doi.org/10.1038/nmeth.2022)
• Synthetic Bio-nanoreactor: Mechanical and Chemical Control of Polymersome Membrane Permeability. Angew Chem Int Ed Engl. 2012 Apr 27;51(18):4448-51
  Gaitzsch J, Appelhans D, Wang L, Battaglia G, Voit B
  (See online at https://doi.org/10.1002/anie.201108814)
• A genomic toolkit to investigate kinesin and myosin motor function in cells. Nat Cell Biol. 2013 Mar;15(3):325-34
  Maliga Z, Junqueira M, Toyoda Y, Ettinger A, Mora-Bermúdez F, Klemm RW, Vasilj A, Guhr E, Ibarlucea-Benitez I, Poser I, Bonifacio E, Huttner WB, Shevchenko A, Hyman AA
  (See online at https://doi.org/10.1038/ncb2689)
• ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing. Genes Dev. 2013 Jul 1;27(13):1484-94
  Royo H, Prosser H, Ruzankina Y, Mahadevaiah SK, Cloutier JM, Baumann M, Fukuda T, Höög C, Tóth A, de Rooij DG, Bradley A, Brown EJ, Turner JM
  (See online at https://doi.org/10.1101/gad.219477.113)
• Defined Polymer-Peptide Conjugates to Form Cell-Instructive starPEG-Heparin Matrices In Situ. Adv Mater. 2013 May 14;25(18):2606-10
  Tsurkan MV, Chwalek K, Prokoph S, Zieris A, Levental KR, Freudenberg U, Werner C
  (See online at https://doi.org/10.1002/adma.201300691)
• Dynamic Guiding of Motor-Driven Microtubules on Electrically Heated, Smart Polymer Tracks. Nano Lett. 2013 Jun 10
  Schroeder V, Korten T, Linke H, Diez S, Maximov I
  (See online at https://doi.org/10.1021/nl402004s)
• Dynein motion switches from diffusive to directed upon cortical anchoring. Cell. 2013 Jun 20;153(7):1526-36
  Ananthanarayanan V, Schattat M, Vogel SK, Krull A, Pavin N, Tolić-Nørrelykke IM
  (See online at https://doi.org/10.1016/j.cell.2013.05.020)
• Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape. Nat Biotechnol. 2013 Jul;31(7):638-46
  Gilleron J, Querbes W, Zeigerer A, Borodovsky A, Marsico G, Schubert U, Manygoats K, Seifert S, Andree C, Stöter M, Epstein-Barash H, Zhang L, Koteliansky V, Fitzgerald K, Fava E, Bickle M, Kalaidzidis Y, Akinc A, Maier M, Zerial M
  (See online at https://doi.org/10.1038/nbt.2612)
• Integration of chemical and RNAi multiparametric profiles identifies triggers of intracellular mycobacterial killing. Cell Host Microbe. 2013 Feb 13;13(2):129-42
  Sundaramurthy V, Barsacchi R, Samusik N, Marsico G, Gilleron J, Kalaidzidis I, Meyenhofer F, Bickle M, Kalaidzidis Y, Zerial M
  (See online at https://doi.org/10.1016/j.chom.2013.01.008)
• Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains. Dev Cell. 2013 Aug 26;26(4):331-45
  Özhan G, Sezgin E, Wehner D, Pfister AS, Kühl SJ, Kagermeier-Schenk B, Kühl M, Schwille P, Weidinger G
  (See online at https://doi.org/10.1016/j.devcel.2013.07.020)
• Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains. Dev Cell. 2013 Aug 26;26(4):331-45
  Özhan G, Sezgin E, Wehner D, Pfister AS, Kühl SJ, Kagermeier-Schenk B, Kühl M, Schwille P, Weidinger G
  (See online at https://doi.org/10.1016/j.devcel.2013.07.020)
• Neuroinflammation and central nervous system regeneration in vertebrates. Trends Cell Biol. 2013 Sep 9. Review. doi:pii: S0962-8924(13)00137-2
  Kyritsis N, Kizil C, Brand M
  (See online at https://doi.org/10.1016/j.tcb.2013.08.004)
• OpenSPIM: an open-access light-sheet microscopy platform. Nat Methods. 2013 Jul;10(7):598-9
  Pitrone PG, Schindelin J, Stuyvenberg L, Preibisch S, Weber M, Eliceiri KW, Huisken J, Tomancak P
  (See online at https://doi.org/10.1038/nmeth.2507)
• Pivoting of microtubules around the spindle pole accelerates kinetochore capture. Nat Cell Biol. 2013 Jan;15(1):82-7
  Kalinina I, Nandi A, Delivani P, Chacón MR, Klemm AH, Ramunno-Johnson D, Krull A, Lindner B, Pavin N, Tolić-Nørrelykke IM
  (See online at https://doi.org/10.1038/ncb2640)
• Progenitor networking in the fetal primate neocortex. Neuron. 2013 Oct 16;80(2):259-62
  Huttner WB, Kelava I, Lewitus E
  (See online at https://doi.org/10.1016/j.neuron.2013.10.004)
• Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators. Genome Res. 2013 Oct 22
  Scheibe M, Arnoult N, Kappei D, Buchholz F, Decottignies A, Butter F, Mann M
  (See online at https://doi.org/10.1101/gr.151878.112)
• Reactivating head regrowth in a regeneration-deficient planarian species. Nature. 2013 Aug 1;500(7460):81-4
  Liu SY, Selck C, Friedrich B, Lutz R, Vila-Farré M, Dahl A, Brandl H, Lakshmanaperumal N, Henry I, Rink JC
  (See online at https://doi.org/10.1038/nature12414)
• Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals. PLoS Biol. 2013 Mar;11(3):e1001505
  Palm W, Swierczynska MM, Kumari V, Ehrhart-Bornstein M, Bornstein SR, Eaton S
  (See online at https://doi.org/10.1371/journal.pbio.1001505)
• The helicase-like domains of type III restriction enzymes trigger long-range diffusion along DNA. Science. 2013 Apr 19;340(6130):353-6
  Schwarz FW, Tóth J, van Aelst K, Cui G, Clausing S, Szczelkun MD, Seidel R
  (See online at https://doi.org/10.1126/science.1231122)
• Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments. Nat Methods. 2013 Aug;10(8):788-9
  Prewitz MC, Seib FP, von Bonin M, Friedrichs J, Stißel A, Niehage C, Müller K, Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C
  (See online at https://doi.org/10.1038/nmeth.2523)
• A wax ester promotes collective host finding in the nematode Pristionchus pacificus. Nat Chem Biol. 2014 Apr;10(4):281-5
  Penkov S, Ogawa A, Schmidt U, Tate D, Zagoriy V, Boland S, Gruner M, Vorkel D, Verbavatz JM, Sommer RJ, Knölker HJ, Kurzchalia TV
  (See online at https://doi.org/10.1038/nchembio.1460)
• An adaptive threshold in mammalian neocortical evolution. PLoS Biol. 2014 Nov 18;12(11):e1002000
  Lewitus E, Kelava I, Kalinka AT, Tomancak P, Huttner WB
  (See online at https://doi.org/10.1371/journal.pbio.1002000)
• Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology. 2014 Oct;60(4):1196-210
  Chatzigeorgiou A, Chung KJ, Garcia-Martin R, Alexaki VI, Klotzsche-von Ameln A, Phieler J, Sprott D, Kanczkowski W, Tzanavari T, Bdeir M, Bergmann S, Cartellieri M, Bachmann M, Nikolakopoulou P, Androutsellis-Theotokis A, Siegert G, Bornstein SR, Muders MH, Boon L, Karalis KP, Lutgens E, Chavakis T
  (See online at https://doi.org/10.1002/hep.27233)
• Fusion of protein aggregates facilitates asymmetric damage segregation. PLoS Biol. 2014 Jun 17;12(6):e1001886
  Coelho M, Lade SJ, Alberti S, Gross T, Tolić IM
  (See online at https://doi.org/10.1371/journal.pbio.1001886)
• Genome-wide RNA Tomography in the zebrafish embryo.Cell. 2014 Oct 23;159(3):662-75
  Junker JP, Noël ES, Guryev V, Peterson KA, Shah G, Huisken J, McMahon AP, Berezikov E, Bakkers J, van Oudenaarden A
  (See online at https://doi.org/10.1016/j.cell.2014.09.038)
• High-resolution reconstruction of the beating zebrafish heart. Nat Methods. 2014 Sep;11(9):919-22
  Mickoleit M, Schmid B, Weber M, Fahrbach FO, Hombach S, Reischauer S, Huisken J
  (See online at https://doi.org/10.1038/nmeth.3037)
• Kit regulates HSC engraftment across the human-mouse species barrier. Cell. 2014 Aug 7;15(2):227-38
  Cosgun KN, Rahmig S, Mende N, Reinke S, Hauber I, Schäfer C, Petzold A, Weisbach H, Heidkamp G, Purbojo A, Cesnjevar R, Platz A, Bornhäuser M, Schmitz M, Dudziak D, Hauber J, Kirberg J, Waskow C
  (See online at https://doi.org/10.1016/j.stem.2014.06.001)
• Microinjection of membrane-impermeable molecules into single neural stem cells in brain tissue. Nat Protoc. 2014 May;9(5):1170-82
  Wong FK, Haffner C, Huttner WB, Taverna E
  (See online at https://doi.org/10.1038/nprot.2014.074)
• Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development. Genes Dev. 2014 Dec 1;28(23):2636-51
  Rodenfels J, Lavrynenko O, Ayciriex S, Sampaio JL, Carvalho M, Shevchenko A, Eaton S
  (See online at https://doi.org/10.1101/gad.249763.114)
• Shape-controlled synthesis of gold nanostructures using DNA origami molds. Nano Lett. 2014 Nov 12;14(11):6693-8
  Helmi S, Ziegler C, Kauert DJ, Seidel R
  (See online at https://doi.org/10.1021/nl503441v)
• Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 2014 Apr 17;40(4):477- 89
  Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK
  (See online at https://doi.org/10.1016/j.immuni.2014.04.004)
• The Coilin Interactome Identifies Hundreds of Small Noncoding RNAs that Traffic through Cajal Bodies. Mol Cell. 2014 Nov 6;56(3):389-99
  Machyna M, Kehr S, Straube K, Kappei D, Buchholz F, Butter F, Ule J, Hertel J, Stadler PF, Neugebauer KM
  (See online at https://doi.org/10.1016/j.molcel.2014.10.004)
• Tissue-engineered 3D tumor angiogenesis models: Potential technologies for anti-cancer drug discovery. Adv Drug Deliv Rev. 2014 Dec 15;79-80C:30-39
  Chwalek K, Bray LJ, Werner C
  (See online at https://doi.org/10.1016/j.addr.2014.05.006)
• Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology. Nat Protoc. 2014 Dec;9(12):2809-22
  Marciniak A, Cohrs CM, Tsata V, Chouinard JA, Selck C, Stertmann J, Reichelt S, Rose T, Ehehalt F, Weitz J, Solimena M, Slak Rupnik M, Speier S
  (See online at https://doi.org/10.1038/nprot.2014.195)
• A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances. Cell. 2015 Oct 22;163(3):712-23
  Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
  (See online at https://doi.org/10.1016/j.cell.2015.09.053)
• A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation. Cell. 2015 Aug 27;162(5):1066-77
  Patel A, Lee HO, Jawerth L, Maharana S, Jahnel M, Hein MY, Stoynov S, Mahamid J, Saha S, Franzmann TM, Pozniakovski A, Poser I, Maghelli N, Royer LA, Weigert M, Myers EW, Grill S, Drechsel D, Hyman AA, Alberti S
  (See online at https://doi.org/10.1016/j.cell.2015.07.047)
• A Single-Strand Annealing Protein Clamps DNA to Detect and Secure Homology. PLoS Biol. 2015 Aug 13;13(8):e1002213
  Ander M, Subramaniam S, Fahmy K, Stewart AF, Schäffer E
  (See online at https://doi.org/10.1371/journal.pbio.1002213)
• Diffusible crosslinkers generate directed forces in microtubule networks. Cell. 2015 Mar 12;160(6):1159-68
  Lansky Z, Braun M, Lüdecke A, Schlierf M, ten Wolde PR, Janson ME, Diez S
  (See online at https://doi.org/10.1016/j.cell.2015.01.051)
• Effects of high-dose oral insulin on immune responses in children at high risk for type 1 diabetes: the Pre-POINT randomized clinical trial. JAMA. 2015 Apr 21;313(15):1541-9
  Bonifacio E, Ziegler AG, Klingensmith G, Schober E, Bingley PJ, Rottenkolber M, Theil A, Eugster A, Puff R, Peplow C, Buettner F, Lange K, Hasford J, Achenbach P; Pre-POINT Study Group
  (See online at https://doi.org/10.1001/jama.2015.2928)
• Engineering Functional Polymer Capsules toward Smart Nanoreactors. Chem Rev. 2015 Aug 31
  Gaitzsch J, Huang X, Voit B
  (See online at https://doi.org/10.1021/acs.chemrev.5b00241)
• Long non-coding RNAs in corticogenesis: deciphering the non-coding code of the brain. EMBO J. 2015 Oct 29
  Aprea J, Calegari F
  (See online at https://doi.org/10.15252/embj.201592655)
• Quantifying the density and utilization of active sites in non-precious metal oxygen electroreduction catalysts. at Commun. 2015 Oct 21;6:8618
  Sahraie NR, Kramm UI, Steinberg J, Zhang Y, Thomas A, Reier T, Paraknowitsch JP, Strasser P
  (See online at https://doi.org/10.1038/ncomms9618)
• C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility. Nat Commun. 2016 Oct 31;7:13298
  Gómez-H L, Felipe-Medina N, Sánchez-Martín M, Davies OR, Ramos I, García-Tuñón I, de Rooij DG, Dereli I, Tóth A, Barbero JL, Benavente R, Llano E, Pendas AM
  (See online at https://doi.org/10.1038/ncomms13298)
• Corrigendum: Noncovalent Hydrogel Beads as Microcarriers for Cell Culture. Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10549
  Wieduwild R, Krishnan S, Chwalek K, Boden A, Nowak M, Drechsel D, Werner C, Zhang Y
  (See online at https://doi.org/10.1002/anie.201607037)
• Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity. Nat Biotechnol. 2016 Apr;34(4):401-9
  Karpinski J, Hauber I, Chemnitz J, Schäfer C, Paszkowski-Rogacz M, Chakraborty D, Beschorner N, Hofmann-Sieber H, Lange UC, Grundhoff A, Hackmann K, Schrock E, Abi-Ghanem J, Pisabarro MT, Surendranath V, Schambach A, Lindner C, van Lunzen J, Hauber J, Buchholz F
  (See online at https://doi.org/10.1038/nbt.3467)
• FGF8 and SHH substitute for anterior-posterior tissue interactions to induce limb regeneration. Nature. 2016 May 19;533(7603):407-10
  Nacu E, Gromberg E, Oliveira CR, Drechsel D, Tanaka EM
  (See online at https://doi.org/10.1038/nature17972)
• Identification of proliferative and mature β-cells in the islets of Langerhans. Nature. 2016 Jul 21;535(7612):430-4
  Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J, Aichler M, Feuchtinger A, Leitzinger C, Zischka H, Wang-Sattler R, Jastroch M, Tschöp M, Machicao F, Staiger H, Häring HU, Chmelova H, Chouinard JA, Oskolkov N, Korsgren O, Speier S, Lickert H
  (See online at https://doi.org/10.1038/nature18624)
• Inactivation of Cancer Mutations Utilizing CRISPR/Cas9. Natl Cancer Inst. 2016 Aug 30;109(1). pii: djw183
  Gebler C, Lohoff T, Paszkowski-Rogacz M, Mircetic J, Chakraborty D, Camgoz A, Hamann MV, Theis M, Thiede C, Buchholz F
  (See online at https://doi.org/10.1093/jnci/djw183)
• Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice. Nat Cell Biol. 2016 Nov;18(11):1208- 1220
  Stanzione M, Baumann M, Papanikos F, Dereli I, Lange J, Ramlal A, Tränkner D, Shibuya H, de Massy B, Watanabe Y, Jasin M, Keeney S, Tóth A
  (See online at https://doi.org/10.1038/ncb3417)
• Microtubule doublets are double-track railways for intraflagellar transport trains. Science. 2016 May 6;352(6286):721-4
  Stepanek L, Pigino G
  (See online at https://doi.org/10.1126/science.a af4594)
• Retinal transplantation of photoreceptors results in donor-host cytoplasmic exchange. Nat Commun. 2016 Oct 4;7:13028
  Santos-Ferreira T, Llonch S, Borsch O, Postel K, Haas J, Ader M
  (See online at https://doi.org/10.1038/ncomms13028)
• Simultaneous Single-Molecule Force and Fluorescence Sampling of DNA Nanostructure Conformations Using Magnetic Tweezers. Nano Lett. 2016 Jan 13;16(1):381-6
  Kemmerich FE, Swoboda M, Kauert DJ, Grieb MS, Hahn S, Schwarz FW, Seidel R, Schlierf M
  (See online at https://doi.org/10.1021/acs.nanolett.5b03956)
• The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis. Blood. 2016 Nov 10;128(19):2285-2296
  Schoedel KB, Morcos MNF, Zerjatke T, Roeder I, Grinenko T, Voehringer D, Göthert JR, Waskow C, Roers A, Gerbaulet A
  (See online at https://doi.org/10.1182/blood- 2016-03-706010)
• A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity. Nat Immunol. 2017 Jun;18(6):654-664
  Chung KJ, Chatzigeorgiou A, Economopoulou M, Garcia-Martin R, Alexaki VI, Mitroulis I, Nati M, Gebler J, Ziemssen T, Goelz SE, Phieler J, Lim JH, Karalis KP, Papayannopoulou T, Blüher M, Hajishengallis G, Chavakis T
  (See online at https://doi.org/10.1038/ni.3728)
• Bottom-Up Structuring and Site-Selective Modification of Hydrogels Using a Two-Photon [2+2] Cycloaddition of Maleimide. Adv Mater. 2017 Jan;29(2)
  Jungnickel C, Tsurkan MV, Wogan K, Werner C, Schlierf M
  (See online at https://doi.org/10.1002/adma.201603327)
• Calcium Directly Regulates Phosphatidylinositol 4,5-Bisphosphate Headgroup Conformation and Recognition. Am Chem Soc. 2017 Mar 22;139(11):4019-4024
  Bilkova E, Pleskot R, Rissanen S, Sun S, Czogalla A, Cwiklik L, Róg T, Vattulainen I, Cremer PS, Jungwirth P, Coskun Ü
  (See online at https://doi.org/10.1021/jacs.6b11760)
• Changes in microtubule overlap length regulate kinesin-14-driven microtubule sliding. Nat Chem Biol. 2017 Oct 16
  Braun M, Lansky Z, Szuba A, Schwarz FW, Mitra A, Gao M, Lüdecke A, Ten Wolde PR, Diez S
  (See online at https://doi.org/10.1038/nchembio.2495)
• Development of a genetic sensor that eliminates p53 deficient cells. Nat Commun. 2017 Nov 13;8(1):1463
  Mircetic J, Dietrich A, Paszkowski- Rogacz M, Krause M, Buchholz F
  (See online at https://doi.org/10.1038/s41467-017- 01688-w)
• Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nat Commun. 2017 Sep 22;8(1):664
  Singh SP, Janjuha S, Hartmann T, Kayisoglu Ö, Konantz J, Birke S, Murawala P, Alfar EA, Murata K, Eugster A, Tsuji N, Morrissey ER, Brand M, Ninov N
  (See online at https://doi.org/10.1038/s41467-017-00461-3)
• Dipolar Relaxation Dynamics at the Active Site of an ATPase Regulated by Membrane Lateral Pressure. Angew Chem Int Ed Engl. 2017 Jan 24;56(5):1269-1272
  Fischermeier E, Pospíšil P, Sayed A, Hof M, Solioz M, Fahmy K
  (See online at https://doi.org/10.1002/anie.201611582)
• Dynamic stepwise opening of integron attC DNA hairpins by SSB prevents toxicity and ensures functionality. Nucleic Acids Res. 2017 Oct 13;45(18):10555-10563
  Grieb MS, Nivina A, Cheeseman BL, Hartmann A, Mazel D, Schlierf M
  (See online at https://doi.org/10.1093/nar/gkx670)
• Forbidden Chemistry: Two-Photon Pathway in [2+2] Cycloaddition of Maleimides. J Am Chem Soc. 2017 Aug 2;139(30):10184-10187
  Tsurkan MV, Jungnickel C, Schlierf M, Werner C
  (See online at https://doi.org/10.1021/jacs.7b04484)
• Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice. Sci Transl Med. 2017 Apr 19;9(386). pii: eaai9044
  Lohmann N, Schirmer L, Atallah P, Wandel E, Ferrer RA, Werner C, Simon JC, Franz S, Freudenberg U
  (See online at https://doi.org/10.1126/scitranslmed.aai9044)
• Highly-Efficient Guiding of Motile Microtubules on Non-Topographical Motor Patterns. Nano Lett. 2017 Sep 13;17(9):5699-5705
  Reuther C, Mittasch M, Naganathan SR, Grill SW, Diez S
  (See online at https://doi.org/10.1021/acs.nanolett.7b02606)
• Machine learning meets complex networks via coalescent embedding in the hyperbolic space. Nat Commun. 2017 Nov 20;8(1):1615
  Muscoloni A, Thomas JM, Ciucci S, Bianconi G, Cannistraci CV
  (See online at https://doi.org/10.1038/s41467-017-01825-5)
• The contribution of homology arms to nuclease-assisted genome engineering. Nucleic Acids Res. 2017 Jul 27;45(13):8105-8115
  Baker O, Tsurkan S, Fu J, Klink B, Rump A, Obst M, Kranz A, Schröck E, Anastassiadis K, Stewart AF
  (See online at https://doi.org/10.1093/nar/gkx497)
• An E2-ubiquitin thioester-driven approach to identify substrates modified with ubiquitin and ubiquitin-like molecules. Nat Commun. 2018 Nov 14;9(1):4776
  Bakos G, Yu L, Gak IA, Roumeliotis TI, Liakopoulos D, Choudhary JS, Mansfeld J
  (See online at https://doi.org/10.1038/s41467-018-07251-5)
• ATR is a multifunctional regulator of male mouse meiosis. Nat Commun. 2018 Jul 5;9(1):2621
  Widger A, Mahadevaiah SK, Lange J, ElInati E, Zohren J, Hirota T, Pacheco S, Maldonado-Linares A, Stanzione M, Ojarikre O, Maciulyte V, de Rooij DG, Tóth A, Roig I, Keeney S, Turner JMA
  (See online at https://doi.org/10.1038/s41467-018-04850-0)
• Author Correction: The axolotl genome and the evolution of key tissue formation regulators. Nature. 2018 Jul;559(7712):E2
  Nowoshilow S, Schloissnig S, Fei JF, Dahl A, Pang AWC, Pippel M, Winkler S, Hastie AR, Young G, Roscito JG, Falcon F, Knapp D, Powell S, Cruz A, Cao H, Habermann B, Hiller M, Tanaka EM, Myers EW
  (See online at https://doi.org/10.1038/s41586-018-0141-z)
• Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells. J Clin Invest. 2018 Aug 31;128(9):3840-3852
  Alissafi T, Hatzioannou A, Mintzas K, Barouni RM, Banos A, Sormendi S, Polyzos A, Xilouri M, Wielockx B, Gogas H, Verginis P
  (See online at https://doi.org/10.1172/JCI120888)
• Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series. Am Coll Cardiol. 2018 Oct 9;72(15):1829-1844
  Schwarz PEH, Timpel P, Harst L, Greaves CJ, Ali MK, Lambert J, Weber MB, Almedawar MM, Morawietz H
  (See online at https://doi.org/10.1016/j.jacc.2018.07.081)
• Coacervation-Mediated Combinatorial Synthesis of Biomatrices for Stem Cell Culture and Directed Differentiation. Adv Mater. 2018 May;30(22):e1706100
  Wieduwild R, Wetzel R, Husman D, Bauer S, El-Sayed I, Duin S, Murawala P, Thomas AK, Wobus M, Bornhäuser M, Zhang Y
  (See online at https://doi.org/10.1002/adma.201706100)
• Conditional control of fluorescent protein degradation by an auxin-dependent nanobody. Nat Commun. 2018 Aug 17;9(1):3297
  Daniel K, Icha J, Horenburg C, Müller D, Norden C, Mansfeld J
  (See online at https://doi.org/10.1038/s41467-018-05855-5)
• DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB- Jmjd3 pathway. Mol Psychiatry. 2018 Jun;23(6):1410- 1420
  Alexaki VI, Fodelianaki G, Neuwirth A, Mund C, Kourgiantaki A, Ieronimaki E, Lyroni K, Troullinaki M, Fujii C, Kanczkowski W, Ziogas A, Peitzsch M, Grossklaus S, Sönnichsen B, Gravanis A, Bornstein SR, Charalampopoulos I, Tsatsanis C, Chavakis T
  (See online at https://doi.org/10.1038/mp.2017.167)
• Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules. Nat Commun. 2018 Jun 7;9(1):2214
  Lüdecke A, Seidel AM, Braun M, Lansky Z, Diez S
  (See online at https://doi.org/10.1038/s41467-018-04656-0)
• DNA-Mold Templated Assembly of Conductive Gold Nanowires. Nano Lett. 2018 Mar 14;18(3):2116-2123
  Bayrak T, Helmi S, Ye J, Kauert D, Kelling J, Schönherr T, Weichelt R, Erbe A, Seidel R
  (See online at https://doi.org/10.1021/acs.nanolett.8b00344)
• In situ-forming, cell-instructive hydrogels based on glycosaminoglycans with varied sulfation patterns.. Biomaterials. 2018 Oct;181:227-239
  Atallah P, Schirmer L, Tsurkan M, Putra Limasale YD, Zimmermann R, Werner C, Freudenberg U
  (See online at https://doi.org/10.1016/j.biomaterials.2018.07.056)
• Label-Free Detection of Microvesicles and Proteins by the Bundling of Gliding Microtubules. Nano Lett. 2018 Jan 10;18(1):117-123
  Chaudhuri S, Korten T, Korten S, Milani G, Lana T, Te Kronnie G, Diez S
  (See online at https://doi.org/10.1021/acs.nanolett.7b03619)
• Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. 2018 Jan 11;172(1-2):147-161.e12
  Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, Joosten LAB, Isermann B, Lesche M, Petzold A, Simons K, Henry I, Dahl A, Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun Ü, Hajishengallis G, Netea MG, Chavakis T
  (See online at https://doi.org/10.1016/j.cell.2017.11.034)
• Pharmacophore Nanoarrays on DNA Origami Substrates as a Single-Molecule Assay for Fragment- Based Drug Discovery. Angew Chem Int Ed Engl. 2018 Nov 5;57(45):14873-14877
  Kielar C, Reddavide FV, Tubbenhauer S, Cui M, Xu X, Grundmeier G, Zhang Y, Keller A
  (See online at https://doi.org/10.1002/anie.201806778)
• Real-Time Deformability Cytometry: Label-Free Functional Characterization of Cells. Methods Mol Biol. 2018;1678:347-369
  Herbig M, Kräter M, Plak K, Müller P, Guck J, Otto O
  (See online at https://doi.org/10.1007/978-1-4939- 7346-0_15)
• Reprint of: Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention: JACC Health Promotion Series. Am Coll Cardiol. 2018 Dec 11;72(23 Pt B):3071-3086
  Schwarz PEH, Timpel P, Harst L, Greaves CJ, Ali MK, Lambert J, Weber MB, Almedawar MM, Morawietz H
  (See online at https://doi.org/10.1016/j.jacc.2018.10.026)
• Rolling circle amplification shows a sinusoidal template length-dependent amplification bias. Nucleic Acids Res. 2018 Jan 25;46(2):538-545
  Joffroy B, Uca YO, Prešern D, Doye JPK, Schmidt TL
  (See online at https://doi.org/10.1093/nar/gkx1238)
• Simultaneous lineage tracing and cell-type identification using CRISPR-Cas9-induced genetic scars. Nat Biotechnol. 2018 Jun;36(5):469-473
  Spanjaard B, Hu B, Mitic N, Olivares-Chauvet P, Janjuha S, Ninov N, Junker JP
  (See online at https://doi.org/10.1038/nbt.4124)
• Structural Transformation of Wireframe DNA Origami via DNA Polymerase Assisted Gap-Filling. ACS Nano. 2018 Mar 27;12(3):2546-2553
  Agarwal NP, Matthies M, Joffroy B, Schmidt TL
  (See online at https://doi.org/10.1021/acsnano.7b08345)
• Structural Transformation of Wireframe DNA Origami via DNA Polymerase Assisted Gap-Filling. ACS Nano. 2018 Mar 27;12(3):2546-2553
  Agarwal NP, Matthies M, Joffroy B, Schmidt TL
  (See online at https://doi.org/10.1021/acsnano.7b08345)
• A heterodimer of evolved designer-recombinases precisely excises a human genomic DNA locus. Nucleic Acids Res. 2019 Nov 20. pii: gkz1078
  Lansing F, Paszkowski-Rogacz M, Schmitt LT, Martin Schneider P, Romanos TR, Sonntag J, Buchholz F
  (See online at https://doi.org/10.1093/nar/gkz1078)
• Degron-tagged reporters probe membrane topology and enable the specific labelling of membranewrapped structures. AM. Nat Commun. 2019 Aug 2;10(1):3490
  Beer KB, Fazeli G, Judasova K, Irmisch L, Causemann J, Mansfeld J, Wehman AM
  (See online at https://doi.org/10.1038/s41467-019-11442-z)
• FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy. Acta Neuropathol. 2019 Jul;138(1):67-84
  Marrone L, Drexler HCA, Wang J, Tripathi P, Distler T, Heisterkamp P, Anderson EN, Kour S, Moraiti A, Maharana S, Bhatnagar R, Belgard TG, Tripathy V, Kalmbach N, Hosseinzadeh Z, Crippa V, Abo-Rady M, Wegner F, Poletti A, Troost D, Aronica E, Busskamp V, Weis J, Pandey UB, Hyman AA, Alberti S, Goswami A, Sterneckert J
  (See online at https://doi.org/10.1007/s00401-019-01998-x)
• Glia-neuron interactions underlie state transitions to generalized seizures. Nat Commun. 2019 Aug 23;10(1):3830
  Diaz Verdugo C, Myren- Svelstad S, Aydin E, Van Hoeymissen E, Deneubourg C, Vanderhaeghe S, Vancraeynest J, Pelgrims R, Cosacak MI, Muto A, Kizil C, Kawakami K, Jurisch-Yaksi N, Yaksi E
  (See online at https://doi.org/10.1038/s41467-019-11739-z)
• Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes. Mol Cell. 2019 Jun 6;74(5):1069-1085.e11
  Papanikos F, Clément JAJ, Testa E, Ravindranathan R, Grey C, Dereli I, Bondarieva A, Valerio-Cabrera S, Stanzione M, Schleiffer A, Jansa P, Lustyk D, Fei JF, Adams IR, Forejt J, Barchi M, de Massy B, Toth A
  (See online at https://doi.org/10.1016/j.molcel.2019.03.022)
• Structural heterogeneity of attC integron recombination sites revealed by optical tweezers. Nucleic Acids Res. 2019 Feb 28;47(4):1861-1870
  Mukhortava A, Pöge M, Grieb MS, Nivina A, Loot C, Mazel D, Schlierf M
  (See online at https://doi.org/10.1093/nar/gky1258)
• Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives. Prog Retin Eye Res. 2019 Mar;69:1-37. Epub 2018 Nov 13. Review.
  Gasparini SJ, Llonch S, Borsch O, Ader M.
  (See online at https://doi.org/10.1016/j.preteyeres.2018.11.001)