EXC 81:  Cellular Networks: From Analysis of Molecular Mechanisms to a Quantitative Understanding of Complex Functions (CellNetworks)

• Subject Area: Basic Research in Biology and Medicine ; Microbiology, Virology and Immunology ; Neurosciences
• Term: from 2006 to 2019
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 24122740

• Final Report Year: 2019

Final Report Abstract

Within Germany, the Heidelberg Life Science community features an unparalleled number of inter-nationally renowned institutions in very close spatial proximity. Heidelberg is thus home to a critical mass of scientific and technological expertise unique to Germany, and a work force that makes it ideal for a large interdisciplinary cluster aiming at understanding the structure, function and evolu-tion of subcellular and supracellular networks. CellNetworks, founded in 2006, made use of this opportunity by assembling a large number of distinguished groups from Heidelberg molecular life science institutions, as well as specialists from mathematics, computational sciences, chemistry and physics to tackle fundamental questions surrounding network structures and architecture, dy-namics and regulation. Our approach benefitted tremendously from the combination of molecular research and computational approaches and led to a better understanding of cellular processes. A bottom-up process in defining future research topics for special funding within CellNetworks re-sulted in six thrilling projects, the results of which leveraged three new CRCs and one DFG-funded network for electron microscopy. A prerequisite of this success was the additional recruiting of excellent scientists, preferentially at disciplinary interfaces (professorship for protein evolution), or specialists in technology (professor-ships for cryo-electron microscopy and proteomics). Furthermore, ten junior research groups, funded by the cluster, and ten junior groups, funded by the Chica and Heinz Schaller Foundation supporting the cluster´s research, have created an exciting atmosphere for the next generation of scientists. Our new colleagues stimulated the technology-oriented development and dynamic inte-gration of new research questions into our research portfolio in the molecular life sciences in Hei-delberg. In parallel, the development of central core facilities for technical service, project consul-tancy and on-the-job-training became an important interlink among scientists of different disciplines and status groups within the university and our partner institutions. CellNetworks thus was, is and will be a strong driving force for the integration of research in the molecular biosciences in Heidelberg across disciplinary and institutional boundaries, to create and to continuously improve high-end core infrastructure and expertise, as well as support computa-tional approaches. We took particular care to sustain the positions of CellNetworks professorships, leading scientists at core facilities, and members of project management. We envision this invest-ment as a lasting benefit for CellNetworks members and for the life science community in Heidel-berg in general. CellNetworks will continue as central unit of the university to support core facilities in the life sciences.

Link to the final report

https://dx.doi.org/10.2314/KXP:1697276407

Publications

• Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe. 2009 Apr 23;5(4):365-75
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• HIV-1 Nef interferes with host cell motility by deregulation of cofilin. Cell Host Microbe. 2009 Aug 20;6(2):174-86
  Stolp B, Reichman-Fried M, Abraham L, Pan X, Giese SI, Hannemann S, Goulimari P, Raz E, Grosse R and Fackler OT
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• Autoregulatory and repressive inputs localize Hydra Wnt3 to the head organizer. Proc Natl Acad Sci USA. 2011 May 31;108(22):9137-42
  Nakamura Y1, Tsiairis CD, Özbek S, Holstein TW
  (See online at https://doi.org/10.1073/pnas.1018109108)
• Hemoglobins S and C interfere with actin remodeling in Plasmodium falciparum-infected erythrocytes. Science. 2011 Dec 2;334(6060):1283-6
  Cyrklaff M, Sanchez CP, Kilian N, Bisseye C, Simpore J, Frischknecht F, Lanzer M
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• Nuclear calcium-VEGFD signaling controls maintenance of dendrite arborization necessary for memory formation. Neuron. 2011 Jul 14;71(1):117-30
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• Quantitative evaluation of mechanosensing of cells on dynamically tunable hydrogels. J Am Chem Soc. 2011 Feb 9;133(5):1367-74
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• Maturation-dependent HIV-1 surface protein redistribution revealed by fluorescence nanoscopy. Science. 2012 Oct 26;338(6106):524-8
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• SAMHD1 restricts HIV-1 infection in resting CD4+ T cells. Nat Med. 2012 Nov;18(11):1682-7
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  (See online at https://doi.org/10.1038/nm.2964)
• Structure and dynamics of the ATP-bound open conformation of Hsp70 chaperones. Molecular Cell. 2012 Dec 28;48(6):863-74
  Kityk R, Kopp J, Sinning I and Mayer MP
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• Synchronizing nuclear import of ribosomal proteins with ribosome assembly. Science. 2012 Nov 2;338(6107):666-71
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  (See online at https://doi.org/10.1126/science.1226960)
• Tandem fluorescent protein timers for in vivo analysis of protein dynamics. Nat. Biotechnol. 2012 Jun 24;30(7):708-14
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• Detecting endogenous SUMO targets in mammalian cells and tissues. Nat Struct Mol Biol. 2013 Apr;20(4):525-31
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• Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines. Nucleic Acids Res. 2013 Nov;41(21):e199
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  (See online at https://doi.org/10.1093/nar/gkt836)
• AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically-attenuated malarial parasites. Mol Ther. 2014, Dec;22(12):2130-41
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• DENR•MCT-1 Promotes Translation Reinitiation Downstream of uORFs to Control Tissue Growth. Nature. 2014 Aug 14; 512(7513): 208–212
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• FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement. Nat Cell Biol., 2014 Jul;16(7):708-15
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• Genome-wide siRNA screens reveal VAMP3 as a novel host factor required for Uukuniemi virus late penetration. J Virol. 2014 Aug;88(15):8565-78
  Meier R, Franceschini A, Horvath P, Tetard M, Mancini R, von Mering C, Helenius A and Lozach PY
  (See online at https://doi.org/10.1128/JVI.00388-14)
• Impaired path integration and grid cell spatial periodicity in mice lacking GluA1-containing AMPA receptors. J Neurosci. 2014 Apr 30;34(18):6245-59
  Allen K, Gil M, Resnik E, Toader O, Seeburg P, Monyer H
  (See online at https://doi.org/10.1523/JNEUROSCI.4330-13.2014)
• Investigating the role of F-actin in human immunodeficiency virus assembly by live-cell microscopy. J Virol. 2014 Jul;88(14):7904-14
  Rahman SA, Koch P, Weichsel J, Godinez WJ, Schwarz U, Rohr K, Lamb DC, Kräusslich HG and Müller B
  (See online at https://doi.org/10.1128/JVI.00431-14)
• Male-female communication triggers calcium signatures during fertilization in Arabidopsis. Nat Commun. 2014 Aug 22;5:4645
  Denninger P, Bleckmann A, Lausser A, Vogler F, Ott T, Ehrhardt DW, Frommer WB, Sprunck S, Dresselhaus T, Grossmann G
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• Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid. Elife. 2014 Dec 17;3:e04114
  Peng K, Muranyi W, Glass B, Laketa V, Yant SR, Tsai L, Cihlar T, Müller B, Kräusslich HG
  (See online at https://doi.org/10.7554/eLife.04114)
• Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis. Nat Commun. 2014 Dec 23;5:5536
  Watanabe H, Kuhn A, Fushiki M, Agata K, Özbek S, Fujisawa T, Holstein TW
  (See online at https://doi.org/10.1038/ncomms6536)
• The histone-fold protein CHRAC14 influences chromatin composition in response to DNA damage. Cell Rep. 2014 Apr 24;7(2):321-330
  Mathew V, Pauleau AL, Steffen N, Bergner A, Becker PB, Erhardt S
  (See online at https://doi.org/10.1016/j.celrep.2014.03.008)
• Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct non-canonical pathways. Neuron. 2014 Jul 2;83(1):104-21
  Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R
  (See online at https://doi.org/10.1016/j.neuron.2014.05.037)
• Alleviation of off-target effects from vector-encoded shRNA via co-delivered RNA decoys. Proc Natl Acad Sci USA. 2015 Jul 28;112(30):E4007-16
  Mockenhaupt S, Grosse S, Rupp D, Bartenschlager R and Grimm D
  (See online at https://doi.org/10.1073/pnas.1510476112)
• Cytoadhesion of Plasmodium falciparum-infected erythrocytes to chondroitin-4-sulfate is cooperative and shear enhanced. Blood. 2015 Jan 8;125(2):383-91. doi: 10.1182/blood-2014-03-561019
  Rieger H, Yoshikawa HY, Quadt K, Nielsen MA, Sanchez CP, Salanti A, Tanaka M, Lanzer M
  (See online at https://doi.org/10.1182/blood-2014-03-561019)
• Direct observation of ultrafast collective motions in CO myoglobin upon ligand dissociation. Science. 2015 Oct 23;350(6259):445-50
  Barends TRM, Foucar L, Ardevol A, Nass K, Aquila A, Botha S, Doak RB, Falahati K, Hartmann E, Hilpert M, Heinz M, Hoffmann MC, Köfinger J, Koglin JE, Kovacsova G, Liang M, Milathianaki D, Lemke H, Reinstein J, Roome CM, Shoeman RL, Williams GJ, Burghardt I, Hummer G, Boutet S, Schlichting I
  (See online at https://doi.org/10.1126/science.aac5492)
• Fundamental properties of unperturbed haematopoiesis from stem cells in vivo. Nature. 2015 Feb 26;518(7540):542-6
  Busch K, Klapproth K, Barile M, Flossdorf M, Holland-Letz T, Schlenner SM, Reth M, Höfer T, Rodewald HR
  (See online at https://doi.org/10.1038/nature14242)
• LncRNA Khps1 regulates expression of the proto-oncogene SPHK1 via triplex-mediated changes in chromatin structure. Mol Cell. 2015 Nov 19;60(4):626-36
  Postepska-Igielska A, Giwojna A, Gasri-Plotnitsky L, Schmitt N, Dold A, Ginsberg D, Grummt I
  (See online at https://doi.org/10.1016/j.molcel.2015.10.001)
• Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation. Nat Comms. 2015 Dec 4;6:10133
  Jadhav B, McKenna M, Johnson N, High S, Sinning I and Pool MR
  (See online at https://doi.org/10.1038/ncomms10133)
• Mechismo: predicting the mechanistic impact of mutations and modifications on molecular interactions. Nucleic Acids Research, 43.2: e10, 2015
  Betts MJ, Lu Q, Jiang YY, Drusko A, Wichmann O, Utz M, Valtierra-Gutiérrez IA, Schlesner M, Jaeger N, Jones DT, Pfister S, Lichter P, Eils R, Siebert R, Bork P, Apic G, Gavin AC, Russell RB
  (See online at https://doi.org/10.1093/nar/gku1094)
• Modulation of Presynaptic Release Probability by the Vertebrate-Specific Protein Mover. Neuron. 2015 Aug 5;87(3):521-33
  Körber C, Horstmann H, Venkatamarani V, Herrmannsdörfer F, Kremer T, Kaiser M, Schwenger DB, Ahmed S, Dean C, Dresbach T and Kuner T
  (See online at https://doi.org/10.1016/j.neuron.2015.07.001)
• NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication. MBio. 2015 Jul 7;6(4):e00759
  Romero-Brey I, Berger C, Kallis S, Kolovou A, Paul D, Lohmann V, Bartenschlager R
  (See online at https://doi.org/10.1128/mBio.00759-15)
• The exosome is recruited to RNA substrates through specific adapter proteins. Cell. 2015 Aug 27;162(5):1029-38
  Thoms M, Thomson E, Baßler J, Gnädig M, Griesel S and Hurt E
  (See online at https://doi.org/10.1016/j.cell.2015.07.060)
• Transcriptional refractoriness is dependent on core promoter architecture. Nat Commun. 2015 Apr 8;6:6753
  Cesbron F, Oehler M, Ha N, Sancar G, Brunner M
  (See online at https://doi.org/10.1038/ncomms7753)
• Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor. Nat Commun. 2015 Mar 9;6:6461
  Schimer J, Pavova M, Anders M, Pachl P, Sácha P, Cigler P, Weber J, Majer P, Rezácová P, Kräusslich HG, Müller B and Konvalinka J
  (See online at https://doi.org/10.1038/ncomms7461)
• Zincfinger nuclease-based double strand breaks attenuate malaria parasites and reveal rare microhomology mediated end joining. Genome Biology. 2015 Nov 17;16:249
  Singer M, Marshall J, Heiss K, Mair GR, Grimm D, Mueller AK and Frischknecht F
  (See online at https://doi.org/10.1186/s13059-015-0811-1)
• (2016) MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation. Nat Commun. 2016 Jun 24;7:11807
  Shostak A, Ruppert B, Ha N, Bruns P, Toprak UH; ICGC MMML-Seq Project, Eils R, Schlesner M, Diernfellner A, Brunner M
  (See online at https://doi.org/10.1038/ncomms11807)
• A genetic interaction map of cell cycle regulators. Molecular Biology of the Cell, 2016
  Billmann M, Horn T, Fischer B, Sandmann T, Huber W, and Boutros M
  (See online at https://doi.org/10.1091/mbc.E15-07-0467)
• A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing. Neuron. 2016 Mar 16;89(6):1291-1304
  Eliava M, Melchior M, Knobloch-Bollmann HS, Wahis J, da Silva Gouveia M, Tang Y, Ciobanu AC, Triana Del Rio R, Roth LC, Althammer F, Chavant V, Goumon Y, Gruber T, Petit- Demoulière N, Busnelli M, Chini B, Tan LL, Mitre M, Froemke RC, Chao MV, Giese G, Sprengel R, Kuner R, Poisbeau P, Seeburg PH, Stoop R, Charlet A, Grinevich V
  (See online at https://doi.org/10.1016/j.neuron.2016.01.041)
• ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores. J Cell Biol. 2016 Mar 14;212(6):647-59
  Isokane M, Walter T, Mahen R, Nijmeijer B, Hériché J-K, Miura K, Maffini S, Ivanov MP, Kitajima TS, Peters J-M and Ellenberg J
  (See online at https://doi.org/10.1083/jcb.201408089)
• Blocking sense strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA. EMBO Mol Med. 2016 Sep 1;8(9):1082-98
  Michler T, Grosse S, Mockenhaupt S, Röder N, Stückler F, Knapp B, Ko C, Heikenwälder M, Protzer U, and Grimm D.
  (See online at https://doi.org/10.15252/emmm.201506172)
• Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses. Cell Host Microbe. 2016 Sep 14;20(3):342-356
  Chatel-Chaix L, Cortese M, Romero-Brey I, Bender S, Neufeldt CJ, Fischl W, Scaturro P, Schieber N, Schwab Y, Fischer B, Ruggieri A, Bartenschlager R
  (See online at https://doi.org/10.1016/j.chom.2016.07.008)
• Differential use of the C-type lectins L-SIGN and DC-SIGN for phlebovirus endocytosis. Traffic. 2016 Jun;17(6):639-56
  Léger P, Tetard M, Youness B, Cordes N, Rouxel RN, Flamand M, and Lozach PY
  (See online at https://doi.org/10.1111/tra.12393)
• Dnmt3a2: a hub for enhancing cognitive functions. Mol Psychiatry. 2016 Aug;21(8):1130-6
  Oliveira AMM, Hemstedt TJ, Freitag HE, and Bading H
  (See online at https://doi.org/10.1038/mp.2015.175)
• Expanding the Circuitry of Pluripotency by Selective Isolation of Chromatin-Associated Proteins. Mol Cell. 2016 Nov 3;64(3):624-635
  Rafiee MR, Girardot C, Sigismondo G, Krijgsveld J
  (See online at https://doi.org/10.1016/j.molcel.2016.09.019)
• Force-producing ADP state of myosin bound to actin. Proc Natl Acad Sci USA. 2016 Mar 29;113(13):E1844-52
  Wulf SF, Ropars V, Fujita-Becker S, Oster M, Hofhaus G, Trabuco LG, Pylypenko O, Sweeney HL, Houdusse AM and Schröder RR
  (See online at https://doi.org/10.1073/pnas.1516598113)
• Frequent mechanical stress suppresses proliferation of mesenchymal stem cells from human bone marrow without loss of multipotency. Sci Rep. 2016 Apr 15;6:24264
  Frank V, Kaufmann S, Wright R, Horn P, Yoshikawa HY, Wuchter P, Madsen J, Lewis AL, Armes SP, Ho AD and Tanaka M
  (See online at https://doi.org/10.1038/srep24264)
• Integration of light and metabolic signals for stem cell activation at the shoot apical meristem. Elife. 2016 Jul 11;5. pii: e17023
  Pfeiffer A, Janocha D, Dong Y, Medzihradszky A, Schöne S, Daum G, Suzaki T, Forner J, Langenecker T, Rempel E, Schmid M, Wirtz M, Hell R, and Lohmann JU
  (See online at https://doi.org/10.7554/eLife.17023)
• MTHFD1 controls DNA methylation in Arabidopsis. Nature Comm. 2016 Jun 13;7:11640
  Groth M, Moissiard G, Wirtz M, Wang H, Garcia-Salinas C, Ramos-Parra PA, Bischof S, Feng S, Cokus SJ, John A, Smith DC, Zhai J, Hale CJ, Long JA, Hell R, Díaz de la Garza RI, Jacobsen SE
  (See online at https://doi.org/10.1038/ncomms11640)
• Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes. Nat Commun. 2016 Nov 8;7:13401
  Cyrklaff M, Srismith S, Nyboer B, Burda K, Hoffmann A, Lasitschka F, Adjalley S, Bisseye C, Simpore J, Mueller AK, Sanchez CP, Frischknecht F, Lanzer M
  (See online at https://doi.org/10.1038/ncomms13401)
• Reovirus intermediate subviral particles constitute a strategy to infect intestinal epithelial cells by exploiting TGF-β dependent pro-survival signaling. Cell. Microbiol. 2016 Dec;18(12):1831-1845
  Stanifer ML, Rippert A, Kazakov A, Willemsen J, Bucher D, Bender S, Bartenschlager R, Binder M and Boulant S
  (See online at https://doi.org/10.1111/cmi.12626)
• Rules and Self-Organizing Properties of Post-embryonic Plant Organ Cell Division Patterns. Curr Biol. 2016 Feb 22;26(4):439-49
  von Wangenheim D, Fangerau J, Schmitz A, Smith RS, Leitte H, Stelzer EHK and Maizel A
  (See online at https://doi.org/10.1016/j.cub.2015.12.047)
• Stimulated Emission Depletion Nanoscopy Reveals Time-Course of Human Immunodeficiency Virus Proteolytic Maturation. ACS Nano. 2016 Sep 27;10(9):8215-22
  Hanne J, Göttfert F, Schimer J, Anders-Össwein M, Konvalinka J, Engelhardt J, Müller B, Hell SW, Kräusslich HG
  (See online at https://doi.org/10.1021/acsnano.6b03850)
• The RanBP2/Ran- GAP1SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes. Nature Comm. 2016 May 10;7:11482
  Ritterhoff T, Das H, Hofhaus G, Schröder RR, Flotho A and Melchior F
  (See online at https://doi.org/10.1038/ncomms11482)
• Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture. Nat Microbiol. 2016 Dec19;2:16247
  Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Vondran FW, De Francesco R, Rice CM, Bartenschlager R, Lohmann V
  (See online at https://doi.org/10.1038/nmicrobiol.2016.247)
• Uukuniemi virus as a tick-borne virus model. J Virol. 2016 Jul 11;90(15):6784-98
  Mazelier M, Rouxel RN, Zumstein M, Mancini R, Bell-Sakyi L, and Lozach PY
  (See online at https://doi.org/10.1128/JVI.00095-16)
• A unique profilin-actin interface is important for malaria parasite motility. PLoS pathog. 2017 May 26;13(5):e1006412
  Moreau CA, Bhargav SP, Kumar H, Quadt KA, Piirainen H, Strauss L, Kehrer J, Streichfuss M, Spatz JP, Wade RC, Kursula I, Frischknecht F
  (See online at https://doi.org/10.1371/journal.ppat.1006412)
• An objective comparison of cell-tracking algorithms. Nat. Methods. 2017 Dec;14(12):1141-1152
  Ulman V, Maška M, Magnusson KEG, Ronneberger O, Haubold C, Harder N, Matula P, Matula P, Svoboda D, Radojevic M, Smal I, Rohr K, Jaldén J, Blau HM, Dzyubachyk O, Lelieveldt B, Xiao P, Li Y, Cho SY, Dufour AC, Olivo-Marin JC, Reyes-Aldasoro CC, Solis-Lemus JA, Bensch R, Brox T, Stegmaier J, Mikut R, Wolf S, Hamprecht FA, Esteves T, Quelhas P, Demirel Ö, Malmström L, Jug F, Tomancak P, Meijering E, Muñoz-Barrutia A, Kozubek M, Ortizde-Solorzano C
  (See online at https://doi.org/10.1038/nmeth.4473)
• Capturing protein communities by structural proteomics in a thermophilic eukaryote. Mol Syst Biol. 2017 Jul 25;13(7):936
  Kastritis PL, O'Reilly FJ, Bock T, Li Y, Rogon MZ, Buczak K, Romanov N, Betts MJ, Bui KH, Hagen WJ, Hennrich ML, Mackmull MT, Rappsilber J, Russell RB, Bork P, Beck M and Gavin AC
  (See online at https://doi.org/10.15252/msb.20167412)
• Differential time-dependent volumetric and surface area changes and delayed induction of new permeation pathways in P. falciparum-infected hemoglobinopathic erythrocytes. Cellular microbiology, 2017; 19:e12650
  Waldecker M, Dasanna AK, Lansche C, Linke M, Srismith S, Cyrklaff M, Sanchez CP, Schwarz US, Lanzer M
  (See online at https://doi.org/10.1111/cmi.12650)
• Evidence for a novel TOR sensing mechanism in higher plants. Nat Comm. 2017 Oct 27;8(1):1174
  Dong Y, Silbermann M, Speiser A, Forieri I, Linster E, Poschet G, Allboje Samami A, Wanatabe M, Sticht C, Teleman AA, Deragon JM, Saito K, Hell R, Wirtz M
  (See online at https://doi.org/10.1038/s41467-017-01224)
• Genome packaging of reovirus is mediated by the scaffolding property of the microtubule network. Cell Microbiol. 2017 Dec;19(12)
  Shah PNM, Stanifer ML, Höhn K, Engel U, Haselmann U, Bartenschlager R, Kräusslich HG, Krijnse Locker J, and Boulant S
  (See online at https://doi.org/10.1111/cmi.12765)
• Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components. Elife. 2017 Jul 19;6. pii: e28985
  Steringer JP, Lange S, Čujová S, Šachl R, Poojari C, Lolicato F, Beutel O, Müller HM, Unger S, Coskun Ü, Honigmann A, Vattulainen I, Hof M, Freund C, Nickel W
  (See online at https://doi.org/10.7554/eLife.28985)
• Loss of GET pathway orthologues in Arabidopsis thaliana causes root hair growth defects and affects SNARE abundance. Proc Natl Acad Sci USA. 2017 Feb 21;114(8):E1544-E1553
  Xing S, Mehlhorn D, Wallmeroth N, Asseck LY, Kar R, Voß A, Denninger P, Schmidt VAF, Schwarzländer M, Stierhof YD, Grossmann G and Grefen C
  (See online at https://doi.org/10.1073/pnas.1619525114)
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