Impact of Candida albicans colonization, dietary factors and B-cells for systemic candidiasis (C05)

• Subject Area: Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology ; Immunology ; Pathology
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 210879364

Project C5 challenges the central dogma in the Candida research community which holds that C. albicans is not a natural colonizer of mice and that the gut microbiota of mice causes colonization resistance. The mechanisms by which diet influences colonization remain unclear and will thus be investigated in the third funding period. Since B-cell-depleted mice are highly susceptible to systemic candidiasis, C5 will explore how different B-cell functions impact systemic candidiasis, using knockout mice and mixed bone marrow chimeras.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 124: Pathogenic Fungi and their Human Host: Networks of Interaction - FungiNet
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Michael Bauer, until 6/2021; Professorin Dr. Ilse Denise Jacobsen; Professorin Dr. Berit Jungnickel