Inhibition of ether-phosphatidylserine synthesis and signaling for tumor therapy (B06)

• Subject Area: Toxicology, Laboratory Medicine
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 204083920

The project asks if acute pharmacological or genetic inhibition of phosphatidylserine synthase 1 suppresses tumor development murine and human models, also in combination with current therapy approaches. Moreover, mechanisms how ether phosphatidylserine (ePS) affects PS externalization will be investigated, and a potential signaling function of lyso-ePS in tumor and immune cells will be tested.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1039: Signalling by Fatty Acid Derivatives and Sphingolipids in Health and Disease
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Andreas Weigert