Design and synthesis of pharmacological tools for G-protein coupled receptors of oxidized lipid mediators (A07)

• Subject Area: Pharmacy
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 204083920

Plans to develop novel pharmacological tools to enable the investigation of the G-protein coupled receptors BLT2, G2A and GPR75. These receptors are modulated by oxidized fatty acid metabolites and are coupled to Gq-mediated signal transduction. A fluorescent ligand for BLT2 will be synthesized and characterized to study the role of the receptor in colitis. For G2A the structure activity relationships (SAR) will be investigated, while for GPR75 it is planned to identify first synthetic ligands.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1039: Signalling by Fatty Acid Derivatives and Sphingolipids in Health and Disease
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Eugen Proschak