The role of the histone H2A deubiquitinase MYSM1 in haematopoiesis and the immune response

• Applicant: Michael Förster, Ph.D.
• Subject Area: Immunology
• Term: from 2013 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 237171680

• Final Report Year: 2015

Final Report Abstract

We have thoroughly investigated the role of Mysm1 in the development of the adaptive immune system. In addition, we investigated its role in haematopoietic stem cell function and blood cell development. Within the scope of the allocated time period funded by the DFG, we finalized a project on Usp21, a deubiquitinase related to Mysm1.

Publications

• The H2A deubiquitinase Mysm1 is Essential for Normal Fetal Hematopoiesis and for the Maintenance of Hematopoietic Stem Cells in Adult Bone Marrow. Stem Cells and Development, 2015 Aug 15;24(16):1865-77
  Förster M., Bell J.I. Petrov J.C., Clare S., Nijnik A.
  (See online at https://doi.org/10.1089/scd.2015.0058)
• Ubiquitin Specific Protease 21 is dispensable for normal development, hematopoiesis and immunity. PLOS One 2015 Feb 13;10(2):e0117304
  Pannu J., Belle J.I., Förster M., Duerr C.U., Shen S., Kane L., Harcourt K., Fritz J.H., Clare S., Nijnik A.
  (See online at https://doi.org/10.1371/journal.pone.0117304)
• A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells. Immunology Vol 151 Issue 1, May 2017, Pages 110-121
  Förster M., Boora R.K., Petrov J.C., Fodil N., Albanese I., Gros P., Kim J., Nijnik A.
  (See online at https://doi.org/10.1111/imm.12710)