Electron-driven protonation dynamics in cytochrome c oxidase (A01)

• Subject Area: Biophysics
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 221545957

In this project state-of-the-art vibrational spectroscopic methods are applied to obtain a molecular understanding of the interplay between redox chemistry, oxygen reduction and protonation dynamics in cytochrome c oxidase. By combining resonance Raman and IR spectroscopy with electrochemical techniques we will monitor key functional groups in proton translocation such as Y288, R473 and heme propionates on the μs-s time scale and as a function of the applied potential.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1078: Protonation Dynamics in Protein Function
• Applicant Institution: Freie Universität Berlin
• Project Heads: Professor Dr. Joachim Heberle; Professorin Dr. Inez Weidinger