pH-dependent Wnt-Signaling Activation and Gastric Carcinogenesis

• Applicant: Dr. Peter Walentek
• Subject Area: Pathology
• Term: from 2012 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 232231485

• Final Report Year: 2015

Final Report Abstract

Taken together, during my postdoctoral training, I have investigated pH-dependency and post-transcriptional regulation of Wnt signaling and ciliogenesis; expanded the knowledge on ATP4-dependent processes during vertebrate development and human disease; started to investigate the underlying cause of ciliated metaplasia in mice and the role of NHE3 during Xenopus development. During this work, I expanded my skills towards working with mice and adult tissue, as well as human cell culture. Furthermore, I could improve my expertise in Xenopus biology, general molecular and developmental biology, regulation of mucociliary epithelia and motile ciliogenesis, as well as advanced microscopy, genetics and post-transcriptional regulation.

Publications

• 2014. microRNAs and cilia – An ancient connection. Cell Cycle 13:15, 1–2; August 1, 2014
  Walentek, P., Song, R., He, L.
  (See online at https://doi.org/10.4161/cc.29827)
• 2014. miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110. Nature 510, 115–120
  Song, R., Walentek, P., Sponer, N., Klimke, A., Lee, J.S., Dixon, G., Harland, R., Wan, Y., Lishko, P., Lize, M., Kessel, M., He, L.
  (See online at https://doi.org/10.1038/nature13413)
• 2015. The Alternative Splicing Regulator Tra2b Is Required for Somitogenesis and Regulates Splicing of an Inhibitory Wnt11b Isoform. Cell Reports (2015), 10, 1–10. February 3, 2015
  Dichmann, D.S., Walentek, P., Harland, R.M.
  (See online at https://doi.org/10.1016/j.celrep.2014.12.046)