TCR Tuning by Transient and Persistent Antigen Presentation (B07)

• Subject Area: Immunology
• Term: from 2013 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 210592381

Using a mouse model which allows reversible antigen presentation in vivo the features and fates of CD8+ T cells exhaustion solely by antigen will be explored. The aim of the project is to investigate the degree and reversibility of the exhausted state by tissue grafts, autoimmunity induction and viral challenges and by analysing the cells' transcriptome and epigenetic modifications. In addition it will be studied how a modified mouse herpesvirus expressing the same antigen persists without exhausting the respective T cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1054: Control and Plasticity of Cell-Fate Decisions in the Immune System
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Privatdozent Dr. Reinhard Obst