Project Details
Projekt
Microfluidic Platform to Study the Transport Properties of Model Cell Membranes (B04)
Subject Area
Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
Term
since 2013
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 200049484
A novel 3D microfluidic platform will be used to understand the nature of nascent fusion pores and their expansion kinetics for natural SNARE-TMD mutations and lipidic curvatures (e.g., vesicle sizes) involving C5 and B7. Subcellular organelles such as lipid droplets (LD) will be studied to understand the biophysical mechanism of dynamic partitioning of proteins between free-standing lipid bilayer and LD monolayer with C9, C10, and B7. In secondary projects, it will be explored how hydrophobins and Eap affect electro-poration and permeability of phospholipid bilayers with B1, B2, B7 and A7; artificial signal cascades will be realized with C1, and virus fusion explored with B7.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität des Saarlandes
Project Heads
Jean-Baptiste Fleury, Ph.D.; Professor Dr. Ralf Seemann
