Project Details
Projekt
Cytoskeletal self-organization and cell signalling (A01)
Subject Area
Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
Term
from 2013 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 200049484
Cells respond to external signals, which often induce cell polarization through a rearrangement of the cytoskeleton. How cytoskeletal proteins participate in signal processing is largely unknown. Cytoskeletal self-organization might play an important role in this process. Employing physical descriptions, we will study cytoskeletal dynamics and its functional implications for signaling during cell migration. In particular, we will investigate spontaneous cytoskeletal waves and explore their consequences for migration in 3d. In collaboration with A2 and A9, we will apply our methods to the migration of immune cells.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität des Saarlandes
Project Heads
Dr. Konstantin Doubrovinski; Professor Dr. Karsten Kruse
