Predictors of childhood obesity with progressive cardiometabolic dysfunction (C05)

• Subject Area: Pediatric and Adolescent Medicine
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 209933838

This project aims to test the hypothesis that subphenotypes of childhood obesity with early progressive cardiometabolic deterioration are linked to adipose tissue (AT) dysfunction. We will identify children with risk and resilience factors for early cardiometabolic decompensation from our longitudinal childhood cohorts comprising clinical, environmental and genetic data. We will link those risk factors and subphenotypes with genomic, epigenomic, transcriptomic and proteomic traits from AT and finally assess the functional relevance of the hereby identified molecular candidates in vitro and in vivo.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1052: Obesity Mechanisms
• Applicant Institution: Universität Leipzig
• Project Heads: Dr. Sandra Erbs, until 12/2016; Professorin Dr. Antje Körner