Genetic Modulators of Serum Adipokine Concentrations (C01+)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: from 2013 to 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 209933838

Adipokines are a critical element linking obesity with obesity-related complications such as insulin resistance, dyslipidemia and steatohepatitis. This project will investigate if in addition to well-known anthropometric markers genetic factors determine adipokine release from adipose tissue. Using genome wide association studies (GWAS) with adipokine concentrations (vaspin, chemerin, asprosin and progranulin) and a Meta-GWAS, the projects seeks to identify genes and polymorphisms potentially regulating adipokine expression and secretion. These will be studied functionally in collaboration with the entire CRC. In addition, interaction with insulin resistance, insulin release, markers of obesity and fat distribution will be studied.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1052: Obesity Mechanisms
• Applicant Institution: Universität Leipzig
• Project Heads: Professor Dr. Michael Stumvoll; Professorin Dr. Anke Tönjes