Epigenetic regulation of esophageal cancer (C03)

• Subject Area: Pathology
• Term: from 2012 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 192904750

Esophageal cancers still represent a major challenge in interdisciplinary oncology. This project explores the epigenetic regulation of oesophageal cancers with respect to its pathobiology and therapeutic potential. We shall evaluate how histone modifiers guide squamous to intestinal cell differentiation in the development of oesophageal adenocarcinomas and establish in a genome-wide approach patterns of histone marks, transcriptomes, and mutational profiles. This project aims to validate epigenetic inhibitors for oesophageal cancer in a preclinical setting.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 992: Medical Epigenetics (MEDEP) - From Basic Mechanisms to Clinical Applications
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Silke Laßmann