Chemical Epigenetics – Inhibitors of histone methyltransferases (A04)

• Subject Area: Pharmacy
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 192904750

Histone methylation is a crucial epigenetic event, involved in many pathological processes. In collaboration with B01 we characterised two new lysine methyltransferases (KMTs), named KMT9 and KMT10. In the next funding period we propose to set up a comprehensive assay platform for KMT9 and KMT10 including assays for cellular target engagement. The proposed work will greatly advance the knowledge on KMT9 and KMT10 function in physiology and pathology and uncover their potential in drug development.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 992: Medical Epigenetics (MEDEP) - From Basic Mechanisms to Clinical Applications
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Manfred Jung