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Dendritogenesis of neocortical pyramidal cells and interneurons: regulation by AMPA and NMDA receptors.

Subject Area Developmental Neurobiology
Term from 2012 to 2016
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 225123516
 
Final Report Year 2016

Final Report Abstract

Taken together, the major aims of the proposal were reached: we put the TARPs on the scene in a developmental context. Only the trafficking-competent TARPs were effective. This indicates that the increase of AMPARs at the cell surface and the subsequent increase of the amplitude of AMPAR-mediated currents (measured as calcium events) is the critical trigger for growth. We found evidence for a role of the endogenous AMPA receptors in promoting selectively the growth of apical dendrites of pyramidal neurons, in part during specific time windows and for neurons in specific cortical layers. We proved a role for endogenous γ-8, and presented evidence that the C-terminus is important. Interestingly, none of the TARPs modified the dendritic growth of the multipolar inhibitory interneurons. Although we have no evidence yet for a role of TARPs in interneurons, the positive aspect is that these neurons served as a perfect internal control.

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