Project Details
Projekt
Sensing and intracellular delivery of iron by fungal monothiol glutaredoxins (D05 (B02))
Subject Area
Cell Biology
Term
from 2012 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 192445154
Monothiol glutaredoxins are central components of cellular iron homeostasis. They are involved in iron uptake regulation, iron trafficking, biogenesis of iron-sulfur proteins, and assembly of proteins with iron centers. How monothiol glutaredoxins fulfil these diverse physiological functions is unclear. To elucidate their molecular function, we will employ cell biological, proteomic, biochemical, and biophysical approaches with the aim to identify new interaction partners and to define the molecular mechanism of these glutaredoxins and of their bound [2Fe-2S] cluster.
DFG Programme
Collaborative Research Centres
Applicant Institution
Philipps-Universität Marburg
Project Heads
Professor Dr. Roland Lill; Privatdozent Dr. Ulrich Mühlenhoff
