Steps to clinical xenogeneic cardiac replacement (C08)

• Subject Area: Cardiac and Vascular Surgery ; Immunology
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213602983

Successful preclinical orthotopic pig-to-baboon procedures depend on: (i) stable genetic modifications, (ii) continuous non-ischemic perfusion techniques, (iii) clinically acceptable immunosuppression based on humanised non-thrombogenic anti-CD40/CD40L antibodies and (iv) omitting intrinsic (genetically derived) donor organ overgrowth using mTOR inhibitor rapamycin derivate or genetically-modified minipig breeds. Long-term results will be necessary but also provide in-depth knowledge of the various steps.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 127: Biology of Xenogeneic Cell and Organ Transplantation - From Bench to Bedside
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Dr. Jan-Michael Abicht; Professor Dr. Paolo Brenner; Stefan Buchholz, until 6/2016; Dr. Sonja Guethoff, until 12/2020; Dr. Matthias Längin; Professor Dr. Bruno Reichart