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Optimizing porcine islet macroencapsulation for the treatment of patients with insulin-dependent diabetes mellitus (C04)

Subject Area Endocrinology, Diabetology, Metabolism
Term from 2012 to 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 213602983
 
Islet transplantation represents an effective treatment option for patients with insulin-dependent diabetes, but is limited due to the need for immunosuppression and shortage of donor organs. We have evaluated a strategy of porcine islet macroencapsulation (BetaAir® device) in different transplant models, including non-human primates, for safety, efficacy, and immunoprotective properties. This concept has now entered the application phase for a first clinical pilot trial. In the final funding period we will in parallel optimise on both the pig islet cell material and the device system to further improve insulin diffusion and efficacy for successful clinical application.
DFG Programme CRC/Transregios
 
 

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