Role of the TRC40 pathway in the proteostasis network of cardiomyocytes (A07(B01))

• Subject Area: Cell Biology
• Term: from 2012 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 193793266

Cardiomyocytes feature an elaborate membrane system. Little is known about membrane protein biogenesis and its relevance to disease in this system. Schwappach et al. recently co-discovered a pathway involved in the posttranslational membrane integration of C-terminally membrane-anchored (tailanchored, TA) membrane proteins, the TRC40 pathway. We will therefore tackle the consequences of an impaired cardiac TRC40 pathway, e.g. lack of cardiomyocyte TA protein function, as opposed to a dominant negative activity of mistargeted TA proteins, and address the contribution of the TRC40 pathway to the cardiomyocyte proteostasis network.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1002: Modulatory Units in Heart Failure
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professorin Dr. Blanche Schwappach-Pignataro