The molecular identity, function, and epilepsy-related plasticity of voltage- and calcium-dependent potassium channels in dentate gyrus granule cells of mice and humans.

• Antragsteller: Dr. Jakob Wolfart
• Fachliche Zuordnung: Molekulare Biologie und Physiologie von Nerven- und Gliazellen
• Förderung: Förderung von 2012 bis 2017
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 222858180

We will determine the molecular identity, function, and epilepsy-related plasticity of voltage- and calcium-dependent potassium channels of dentate gyrus granule cells. To this end we will use electrophysiological and molecular biology techniques. Hippocampal tissue of humans obtained during epilepsy surgery and epilepsy animal models will be employed. Using conductance-based computer simulations, we will precisely dissect the functional impact of identified potassium channels under physiological and pathophysiological conditions.

• DFG-Verfahren: Sachbeihilfen