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Genetic basis involved in host interaction and adaptation of Escherichia coli: Impact on crosstalk with cellular barriers (B05)

Subject Area Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
Term from 2012 to 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 194468054
 
We aim at the identification of bacterial properties and the molecular mechanisms involved in different types of host-bacterium interaction at cellular barriers leading to infection or colonization. We want to unravel how bacteria downregulate RNA polymerase II and c-MYC-dependent host gene expression. We also want to understand how epigenetic mechanisms, like histone acetylation and DNA methylation, reprogramme innate immunity during infection with uropathogenic E. coli.
DFG Programme Collaborative Research Centres
Applicant Institution Universität Münster
 
 

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