Project Details
Projekt
The role of MAPK pathways in influenza virus replication and bacterial super-infection (B02)
Subject Area
Virology
Term
from 2012 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 194468054
Influenza viruses are barrier breaking pathogens that exploit cellular pathways to promote their replication. We have identified the Raf/MEK/ERK MAPK pathway to play a crucial role in virus replication and showed that this dependency could be used for a novel anti-influenza approach using MEK inhibitors. In the new funding period, we will not only further study the role of the pathway in ERK-mediated vRNP nuclear export but also explore a newly identified contribution of immunomodulatory activity of MEK inhibitors to prevent virus and even super-infecting bacteria from breaking the immune barrier against infections.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Dr. Yvonne Börgeling; Professorin Dr. Christina Ehrhardt, until 6/2020; Professor Dr. Stephan Ludwig
