Analysis of the Drosophila blood-brain barrier (A04)

• Subject Area: Developmental Biology
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 194468054

The blood-brain barrier in Drosophila is made by a set of specialized septate junction forming cells that establish an endothelial-like sheet around the entire nervous system. We seek to understand the role of tricellular junctions for the dynamics of septate junction formation and their transient opening during inflammation. We previously demonstrated transmigration of macrophages across the Drosophila blood-brain barrier and will now determine the signals that lure the macrophages towards and into the nervous system.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1009: Breaking Barriers - Immune Cells and Pathogens at Cell/Matrix Barriers
• Applicant Institution: Universität Münster
• Project Heads: Professor Dr. Christian Klämbt; Professor Dr. Stefan Luschnig; Professorin Dr. Stefanie Schirmeier