Identification, isolation and characterisation of novel antimicrobial peptides from human tissue as well as the development of therapeutically applicable lead structures

• Applicant: Professor Dr. Nisar Peter Malek, since 6/2019
• Subject Area: Gastroenterology
• Term: from 2012 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 222642086

• Final Report Year: 2021

Final Report Abstract

No abstract available

Publications

• (2017). Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action. PLoS pathogens, 13(3), e1006261
  Raschig, J., Mailänder-Sánchez, D., Berscheid, A., Berger, J., Strömstedt, A. A., Courth, L. F., ... & Wehkamp, J.
  (See online at https://doi.org/10.1371/journal.ppat.1006261)
• (2019). Proteolytic degradation of reduced human beta defensin 1 generates a novel antibiotic octapeptide. Scientific reports, 9(1), 1-12
  Wendler, J., Schroeder, B. O., Ehmann, D., Koeninger, L., Mailänder-Sánchez, D., Lemberg, C., ... & Wehkamp, J.
  (See online at https://doi.org/10.1038/s41598-019-40216-2)
• (2020). Fragmentation of human neutrophil α-defensin 4 to combat multidrug resistant bacteria. Frontiers in Microbiology, 11, 1147
  Ehmann, D., Koeninger, L., Wendler, J., Malek, N. P., Stange, E. F., Wehkamp, J., & Jensen, B. A.
  (See online at https://doi.org/10.3389/fmicb.2020.01147)
• Defensin Fragments to modulate microbiome WO2020144166A1 Aesculus Bio Aps Priority 2019-01-07. Filed 2020-01-07. Published 2020-07-16
  Jan Wehkamp