Symptom-specific functional and structural connectivity of the fronto-striatal circuitry in obsessive-compulsive disorder
Final Report Abstract
Although these findings must be substantiated by further studies they provide first evidence for a direct association between gray matter changes and a specific OCD symptom profile. If we assume that gray matter alterations depend, at least to a large extent, on the clinical profile, then this may explain the considerable result heterogeneity of earlier studies which usually investigated rather heterogeneous patient samples without taking into consideration specific symptom profiles. Hence, large studies, ideally pooling data from multiple OCD sites such as, e.g., the ENIGMA initiative, should make an attempt to further elucidate the clinical relevance of structural brain alterations in OCD by taking into account the psychopathological heterogeneity of the disorder. Perspectively, the identification of clinically relevant alterations may contribute to a better understanding of the neurobiological mechanisms underlying the disorder and its symptom manifestation. Nevertheless, results of the project are not directly economically valuable but can be assumed to advance basis research on the neural substrates of OCD.
Publications
- (2014). Association between white matter fiber structure and reward-related reactivity of the ventral striatum. Human Brain Mapping, 35, 1469-1476
Koch K., Wagner G., Schachtzabel C., Schultz C.C., Güllmar D., Reichenbach J.R., Sauer H., Zimmer C., Schlösser R.G.M.
(See online at https://doi.org/10.1002/hbm.22284) - (2014). Diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD): A review. Journal of Psychiatric Research, 54, 26-35
Koch K., Reeß T.J., Rus O.G., Zimmer C., Zaudig M.
(See online at https://doi.org/10.1016/j.jpsychires.2014.03.006) - (2016). Connectomics-based structural network alterations in obsessive-compulsive disorder. Translational Psychiatry. 6 (9):e882
Reess T.J., Rus O.G., Schmidt R., de Reus M.A., Zaudig M., Wagner G., Zimmer C., van den Heuvel M.P., Koch K.
(See online at https://doi.org/10.1038/tp.2016.163) - (2016). Functional and structural connectivity of the amygdala in obsessive-compulsive disorder. Neuroimage Clinical, 13, 246-255
Rus O.G., Reess T.J., Wagner G., Zimmer C., Zaudig M., Koch K.
(See online at https://doi.org/10.1016/j.nicl.2016.12.007) - (2017). Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. American Journal of Psychiatry, 174, 60-69
Boedhoe P.S., Schmaal L., Abe Y., Ameis S.H., Arnold P.D., Batistuzzo M.C., Benedetti F., Beucke J.C., Bollettini I., Bose A., Brem S., Calvo A., Cheng Y., Cho K.I., Dallaspezia S., Denys D., Fitzgerald K.D., Fouche J.P., Giménez M., Gruner P., Hanna G.L., Hibar D.P., Hoexter M.Q., Hu H., Huyser C., Ikari K., Jahanshad N., Kathmann N., Kaufmann C., Koch K., Kwon J.S., Lazaro L., Liu Y., Lochner C., Marsh R., Martínez-Zalacaín I., Mataix-Cols D., Menchón J.M., Minuzzi L., Nakamae T., Nakao T., Narayanaswamy J.C., Piras F., Piras F., Pittenger C., Reddy Y.C., Sato J.R., Simpson H.B., Soreni N., Soriano-Mas C., Spalletta G., Stevens M.C., Szeszko P.R., Tolin D.F., Venkatasubramanian G., Walitza S., Wang Z., van Wingen G.A., Xu J., Xu X., Yun J.Y., Zhao Q.; ENIGMA OCD Working Group., Thompson P.M., Stein D.J., van den Heuvel O.A.
(See online at https://doi.org/10.1176/appi.ajp.2016.16020201) - (2017). Hypogyrification in obsessive-compulsive disorder, Psychological Medicine, 47, 1053-1061
Rus O.A., Reess T.R., Wagner G., Zaudig M., Zimmer C., Koch K.
(See online at https://doi.org/10.1017/S0033291716003202)
