Project Details
Projekt
FZT 111: Regenerative Therapies: From cells to tissues to therapies - Engineering the cellular basis of regeneration
Subject Area
Medicine
Term
from 2006 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 22137416
An important goal of biomedical research for the 21st century is to understand how to exploit the regenerative capacity of the body for new therapies. Reconstructive therapy is already a reality for the transplantation of haematopoetic stem cells. However, for many major diseases such as diabetes, Morbus Parkinson, Alzheimer, bone/cartilage or myocardial diseases, regenerative therapy is still fiction. The Center for Regenerative Therapies Dresden (CRTD) integrates research in the field of nanotechnology, material science, medicine and biology in order to develope novel strategies for regenerative therapies.
Our main objectives are:
(1) to develop advanced regenerative therapies for haemato-oncological, endocrine, neurodegenerative, bone/cartilage and cardiovascular diseases;
(2) to study the crucial mechanisms controlling stem cell recruitment, activation, proliferation, and differentiation in model organisms;
(3) to control these cellular processes using genetics, surface engineering, matrix engineering and microdevices in order to provide control of stem cell activity and regeneration;
(4) to test the novel regeneration therapies in pre-clinical and clinical trials;
(5) to develop such therapies into marketable products with our commercial partners;
(6) to develop a leading centre for Regenerative Therapies in Europe.
The CRTD uses the financial support by the DFG to
(1) build a novel scientific competence centre within the already existing research network in Dresden. For this competence centre three professors, eight junior group leaders and their groups will be recruited, in order to develop new strategies for regenerative therapies;
(2) support specific projects that integrate novel concepts discovered in basic research into clinical therapie;
(3) support interdisciplinary projects that integrate engineering of biomaterials with basic research in biology or therapies in a clinical setting;
(4) build a technology platform that offers excellent infrastructure for imaging, cell manipulation, biomaterials, clinical cell and tissue technology, bioinformatics, genetics and high-throughput screening.
This programme was successful in the German government's Excellence Initiative and has been funded since November 2006 as DFG Research Centre 111/Cluster of Excellence 168.
Our main objectives are:
(1) to develop advanced regenerative therapies for haemato-oncological, endocrine, neurodegenerative, bone/cartilage and cardiovascular diseases;
(2) to study the crucial mechanisms controlling stem cell recruitment, activation, proliferation, and differentiation in model organisms;
(3) to control these cellular processes using genetics, surface engineering, matrix engineering and microdevices in order to provide control of stem cell activity and regeneration;
(4) to test the novel regeneration therapies in pre-clinical and clinical trials;
(5) to develop such therapies into marketable products with our commercial partners;
(6) to develop a leading centre for Regenerative Therapies in Europe.
The CRTD uses the financial support by the DFG to
(1) build a novel scientific competence centre within the already existing research network in Dresden. For this competence centre three professors, eight junior group leaders and their groups will be recruited, in order to develop new strategies for regenerative therapies;
(2) support specific projects that integrate novel concepts discovered in basic research into clinical therapie;
(3) support interdisciplinary projects that integrate engineering of biomaterials with basic research in biology or therapies in a clinical setting;
(4) build a technology platform that offers excellent infrastructure for imaging, cell manipulation, biomaterials, clinical cell and tissue technology, bioinformatics, genetics and high-throughput screening.
This programme was successful in the German government's Excellence Initiative and has been funded since November 2006 as DFG Research Centre 111/Cluster of Excellence 168.
DFG Programme
DFG Research Centres
Projects
- Bone/Cartilage: Hard Tissue Replacement (Project Heads Hofbauer, Lorenz C. ; Lauer, Günter )
- Cardiovascular Research (Project Head Strasser, Ruth H. )
- Central Administration (Project Heads Brand, Michael ; Tanaka, Ph.D., Elly Margaret )
- Central Administration (Project Head Bonifacio, Ph.D., Ezio )
- Diabetes and Pancreatic Islet Regeneration (Project Heads Bonifacio, Ph.D., Ezio ; Solimena, Michele )
- Hematology/Immunology (Project Head Bornhäuser, Martin )
- Neurodegenerative Disseases and Retina Degeneratiopn (Project Head Storch, Alexander )
- Technology Platform (Project Head Schwille, Petra )
Applicant Institution
Technische Universität Dresden
Spokespersons
Professor Ezio Bonifacio, Ph.D., until 12/2018; Professor Dr. Michael Brand, from 11/2005 until 12/2020; Professor Federico Calegari, Ph.D., since 1/2021; Professorin Elly Margaret Tanaka, Ph.D., from 4/2014 until 5/2016
