Identification and regulation of neural stem cells in the adult mammalian hypothalamus
Final Report Abstract
In summary, this study demonstrates that an important NSC marker gene, Tlx, is specifically expressed by a subpopulation of tanycytes that reside in the 3rdV. These hypothalamic Tlx positive cells comprise a valuable reservoir for hypothalamic neurogenesis in the postnatal and adult mouse brain. Moreover, our findings here also provide evidence for the existence of neurogenesis and expression of Tlx in the 3rdV of postnatal human brain, which further suggests that Tlx expressing cells in the 3rdV of the postnatal brain may be the source of postnatal hypothalamic neurogenesis in humans. Identifying the expression of Tlx in the 3rdV of the postnatal and adult mouse brain and finding out the functional role of Tlx in hypothalamic neurogenesis highlight that Tlx dependent regulation of postnatal and adult neurogenesis might be a general regulatory mechanism in distinct NSC pools of the brain. These findings emphasize the clinical importance of Tlx to treat hypothalamic disorders, neurodegenerations and injuries in the hypothalamus.
Publications
- Identification of a Novel Neural Stem Cell Population in the Hypothalamus of Mammalian Brain. Ruprecht-Karls-Universität Heidelberg ,Germany
Gözde Bekki
