The roles of THOC 5/Fms interacting protein, a member of mRNA export complex THOC, in the immediate-early gene expression induced by a cell differentiation signal.

Applicant Professorin Dr. Teruko Tamura-Niemann (†)

Subject Area Cell Biology

Term from 2012 to 2020

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 217461545

Final Report Year 2020

Final Report Abstract

No abstract available

(2016) Targeting multiple signaling pathways: Depletion of three combined THOC5, mRNA export protein, target genes synergistically induces human hepatocellular carcinoma cell death. Oncogene, 35, 3872- 2879
Saran, S.,Tran, DDH, Ewald, F., Koch, A., Hoffmann, A., Koch, M., Nashan, B., and Tamura, T.
(See online at https://doi.org/10.1038/onc.2015.433)
(2016). mRNA export protein THOC5 as a tool for identification of target genes for cancer therapy. Cancer letters, 373, 222-226
Tran, DDH., Saran, S., Koch, A.,Tamura,T.
(See online at https://doi.org/10.1016/j.canlet.2016.01.045)
(2018) Myc target gene, long intergenic noncoding RNA, Linc00176 in hepatocellular carcinoma regulates cell cycle and cell survival by titrating tumor suppressor microRNAs. Oncogene, 37, 75-85
Tran, DDH., Kessler C., Niehus SE., Mahnkopf M., Koch A., Tamura T.
(See online at https://doi.org/10.1038/onc.2017.312)
(2019) Myc/Max dependent intronic long antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner. Sci Rep;9(1):17319
Niehus, SE., Allister, AB., Hoffmann, A.,Wiehlmann, L., Tamura, T.,Tran, DDH.
(See online at https://doi.org/10.1038/s41598-019-53944-2)