Struktur und Dynamik des Protoonkogens Ras und spezifischer Ras-Mutanten.

Applicant Professor Dr. Hans Robert Kalbitzer

Subject Area Structural Biology

Term from 2006 to 2011

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 21540907

Final Report Year 2011

Final Report Abstract

No abstract available

(2007). Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTPγS. FEBS J. 274, 1419-1433
Spoerner, M., Nuehs, A., Herrmann, C., Steiner, G. & Kalbitzer, H. R.
(2007). Solid-state 31P NMR spectroscopy of precipitated guanine nucleotide-binding protein Ras in complexes with its effector molecules Raf kinase and RalGDS. J. Phys. Chem. B 111, 2752-2757
Ader, A., Spoerner, M., Kalbitzer, H. R. & Brunner, E.
(2009). Fundamental link between folding states and functional states of proteins. J. Am. Chem. Soc. 131, 16714–16719
Kalbitzer, H. R., Spoerner, M., Ganser, P., Hosza, C. and Kremer, W.
(2010). Conformational states of rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector binding and GTP hydrolysis. J. Biol. Chem. 285, 39768–39778
Spoerner, M., Hozsa, C., Poetzl, J. A., Reiss, K., Ganser, P., Geyer, M., and Kalbitzer, H. R.