Cell hydration- and osmolyte-dependence of liver damage and regeneration (A05)

• Subject Area: Gastroenterology
• Term: from 2012 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 190586431

Based on the preliminary work the project investigates ammonium and glutamine metabolism, hepatocyte heterogeneities and the role of ß1-integrin in the sensing/ signalling of cell volume changes, insulin and tauroursodeoxycholate using novel animal models. In the focus are studies on the role of the ammonium transporter RhBG, the taurine transporters TauT and GAT2, liver glutaminase (Gls2) and intercellular glutamine cycling for ammonia homeostasis. Further research topics focus on heterogeneities of perivenous glutamine synthetase-positive perivenous scavenger cells and "protein repair" of mutated glutamine synthetase.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 974: Communication and System Relevance in Liver Injury and Regeneration
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Head: Professor Dr. Dieter Häussinger