Project Details
Projekt
Hepatic Stellate Cells and Liver Regeneration (A02)
Subject Area
Gastroenterology
Term
from 2012 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 190586431
Hepatic stellate cells (HSC) support regenerative processes of the liver by the release of signalling factors. The project aims to unravel the relevance of Wnt5a released by HSC for the maintenance and repair of adult liver. To investigate this, two transgenic rats were established that enable a Wnt5a knockout in HSC either under control of the glial fibrillary acidic protein or the nestin promoter. In addition, mechanisms involved in the release of signalling factors by HSC after their exposure to mechanical forces shall be further elucidated. Finally, the meaning of an altered communication between HSC and sinusoidal endothelial cells during aging will be investigated. The findings of project shall provide deeper insights into mechanisms of liver homeostasis and regeneration involving HSC and how these processes are impaired in diseased and aged liver.
DFG Programme
Collaborative Research Centres
Applicant Institution
Heinrich-Heine-Universität Düsseldorf
Project Heads
Professor Dr. Dieter Häussinger; Dr. Claus Kordes
