Project Details
Projekt
Diatom Nanobiotechnology: Design Principles for Enhancing the Catalytic Activities of Enzymes and Metal Nanoparticles immobilized on Diatom Biosilica
Applicants
Professor Dr. Eike Brunner; Professor Dr. Nils Kröger
Subject Area
Biomaterials
Synthesis and Properties of Functional Materials
Synthesis and Properties of Functional Materials
Term
from 2012 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 210320604
Diatoms are single-celled microorganisms with remarkable SiO2 (silica) forming capabilities. Diatom silica exhibits hierarchical patterns of nano- to mircoscale features, which endow the material with interesting properties that are difficult to reproduce synthetically. The project combines methods for the deposition of inorganic materials under mild reaction conditions with genetic manipulation of diatom silica biogenesis to synthesize hierarchically structured organic-inorganic hybrid materials with interesting optical, catalytic, and magnetic properties. This approach is based on generating transgenic diatom strains that expose tailored functional proteins in selected region of the silica scaffold. In case of mineral forming proteins this is expected to allow for the deposition of inorganic nanoparticles in well defined regions of the silica scaffold. The incorporation of receptor/ligand proteins is aimed at enabling the site-specific attachment of appropriately modified magnetic nanoparticles that have been isolated from magnetotactic bacteria. Through self-assembly of magnetic and receptor/ligand modified diatom silica we aim to generate for the first time ordered 2D and 3D superstructures of this unique biological material.
DFG Programme
Priority Programmes
