Characterization of action control networks in genetically determined parkinsonism (C05)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2011 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 178316478

In the first two funding periods, we found evidence for increased activity of action selection networks in patients with genetically undefined parkinsonism, Parkin- and PINK1-associated parkinsonism, L-dopa-responsive dystonia, and X-linked dystonia parkinsonism. We now focus on network-related processes leading to disease manifestation by comparing asymptomatic mutation carriers with symptomatic patients with Parkin- and PINK1-associated parkinsonism, X-linked dystonia parkinsonism, and GBA-associated parkinsonism. To this end, we will use behavioral tasks, EEG, TMS, pupillometry, and neuromelanin-sensitive high-resolution MRI.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 936: Multi-Site Communication in the Brain
• Applicant Institution: Universität Hamburg
• Project Heads: Professorin Dr. Christine Klein; Professor Dr. Alexander Münchau