Functional analysis of LunaparkA in hindbrain development of zebrafish

• Applicant: Professor Dr. Reinhard W. Köster
• Subject Area: Developmental Neurobiology
• Term: from 2012 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 206676348

• Final Report Year: 2015

Final Report Abstract

Like its counterparts in other organisms, Danio rerio LnpA obviously has essential functions in membrane dynamics and membrane traffic of the endoplasmic reticulum. Together with its conserved partner Atlastin, LnpA may influence the maintenance and/or stability of the endoplasmic reticulum membrane continuum and the trafficking of plasma membrane-bound receptors such as the Bmp receptor. Taken together, Lunapark is now considered to be another potential disease factor for Hereditary Spastic Paraplegia with an important function in endoplasmic reticulum membrane dynamics. The analysis of LnpA in zebrafish will contribute to the understanding of molecular biological and developmental mechanisms underlying this disease.

Publications

• (2015) A molecular toolbox for genetic manipulation of zebrafish. Advances in Genomics and Genetics 5: 151-163
  Sassen, W. A., Köster, R. W.