Transcript elongation by RNA polymerase II and mRNA export in Arabidopsis (A06)

• Subject Area: Plant Biochemistry and Biophysics
• Term: from 2011 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 185476941

Our focus will be on elucidating the mechanism(s) of plant nucleocytosolic mRNA transport and identifying molecular links between transcriptional elongation and mRNA export. We plan investigating (1) how export factors are recruited co-transcriptionally to the mRNP and (2) the functional consequences of the association of different export factors with the RNA helicase UAP56. As UAP56 associated factors ALY/UIEF are diversified in plants, (3) we study their functional specificity/redundancy. (4) We intend to identify the plant mRNA export receptor and elucidate its role in the formation of export-competent mRNPs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 960: Ribosome Formation: Principles of RNP Biogenesis and Control of their Function
• Applicant Institution: Universität Regensburg
• Project Head: Professor Dr. Klaus Grasser