Spatiotemporal model of neuronal signaling and its regulation by presynaptic membrane scaffolds (A04)

• Subject Area: Bioinformatics and Theoretical Biology
• Term: from 2011 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 184695641

Project A04 develops theoretical and computational models of processes involved in neuronal signaling, specifically exo/endocytosis at presynaptic neurons and assembly of protein scaffolds at the membrane. Specifically, we have developed particle-based models for simulating protein recruitment at endo- and exocytic sites and their effect on membrane mechanics. These models are used to derive models of endo- and exocytosis of unprecedented spatiotemporal resolution.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 958: Scaffolding of Membranes: Molecular Mechanisms and Cellular Functions
• Applicant Institution: Freie Universität Berlin
• Project Heads: Professorin Cecilia Clementi, Ph.D., since 10/2022; Professor Dr. Frank Noé, until 9/2022